中药汤剂干预缺血性中风恢复期气虚血瘀证的临床疗效观察

发布时间：2019-01-07 08:11

【摘要】：目的:通过对中药汤剂干预缺血性中风恢复期之气虚血瘀证的临床疗效观察,对中药汤剂的有效性进行评估。材料与方法:所选患者均来自于2014年9月-2015年12月期间,就诊于辽宁中医药大学附属第二医院脑病一科的患者,将符合西医动脉粥样硬化性血栓性脑梗塞诊断标准,符合中医缺血性中风恢复期之气虚血瘀证诊断标准的60例患者纳入试验。根据随机对照的原则将60例受试者分为治疗组、对照组各30例。对照组单纯口服阿司匹林,治疗组在对照组的基础上联合口服中药汤剂,两组均连续治疗28天,总疗程结束后,分别对两组患者服药前、服药后28天的中医证候及神经功能缺损评分进行评估;对两组患者服药前、服药后28天、发病后90天的改良Rankin量表、日常生活能力评定量表(Barthel指数)的评分进行评估。结果:1.两组在治疗前、治疗后的中医证候积分以及神经功能缺损评分均有显著差异(P0.05),但治疗组改善情况优于对照组。2.两组在治疗前、治疗后及发病后90天的改良Rankin、日常生活能力(Barthel指数)评分均有显著差异(P0.05),但治疗组改善情况优于对照组,治疗组在生活相对独立者所占人数上优于对照组。3.用药期间两组均未出现任何不良反应,未出现因为严重不良事件的发生而中断治疗的情况。结论:与单纯使用阿司匹林相比,联合使用中药汤剂在改善缺血性中风恢复期患者的临床症状方面取得了较大疗效。研究表明,中药汤剂可以改善患者的临床症状以及神经功能缺损情况,对患者的生活质量也有大大提高,并对远期预后有着较大强度的改善,在临床应用中值得广泛推广使用。
[Abstract]:Objective: to evaluate the effectiveness of traditional Chinese medicine decoction (TCM) in the treatment of qi deficiency and blood stasis syndrome in the convalescence of ischemic apoplexy. Materials and methods: all the patients selected from September 2014 to December 2015, who were admitted to the Department of Encephalopathy, second affiliated Hospital of Liaoning University of traditional Chinese Medicine, will meet the criteria for diagnosis of atherosclerotic thrombotic cerebral infarction. 60 patients who met the diagnostic criteria of qi deficiency and blood stasis in convalescence of ischemic stroke of TCM were included in the test. According to the principle of random control, 60 subjects were divided into treatment group and control group. The control group took aspirin only, the treatment group combined with oral Chinese medicine decoction on the basis of the control group. The two groups were treated continuously for 28 days. After the total course of treatment, the patients in the two groups were treated before taking medicine respectively. The TCM syndromes and neurological impairment scores were evaluated 28 days after taking medicine. The scores of the modified Rankin scale and the activity of Daily living (Barthel) scale were evaluated before, 28 days and 90 days after the treatment. Results: 1. Before and after treatment, there were significant differences in TCM syndromes score and neurological deficit score between the two groups (P0.05), but the improvement in the treatment group was better than that in the control group. 2. The scores of modified Rankin, daily living index (Barthel index) were significantly different between the two groups before treatment, after treatment and 90 days after onset (P0.05), but the improvement of the treatment group was better than that of the control group. The number of relatively independent people in the treatment group was better than that in the control group. There were no adverse reactions in both groups and no interruption of treatment because of serious adverse events. Conclusion: compared with aspirin alone, combined use of traditional Chinese medicine decoction can improve the clinical symptoms of patients with ischemic stroke. The research shows that the traditional Chinese medicine decoction can improve the clinical symptoms and neurological function defect of the patients, improve the quality of life of the patients greatly, and improve the long-term prognosis greatly. It is worth popularizing in the clinical application.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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