阴虚阳亢型高血压患者与西北燥证、水通道蛋白的关系研究

发布时间：2019-01-07 14:47

【摘要】：目的:观察阴虚阳亢型高血压患者与西北燥证罹患者血清AQP1、尿液AQP2浓度的变化,探讨AQP1、AQP2与新疆地区高血压病、西北燥证发病机理中的内在联系。方法:共收集120例高血压患者与60例体检健康者,分为6组。组1为罹患西北燥证的阴虚阳亢型高血压患者,组2为罹患西北燥证的非阴虚阳亢型高血压患者,组3为未罹患西北燥证的阴虚阳亢型高血压患者,组4为未罹患西北燥证的非阴虚阳亢型高血压患者,组5为罹患西北燥证的体检健康者,组6为未罹患西北燥证的体检健康者。每组各30人。收集所有受试者的血液、尿液标本,用ELISA法检测血清AQP1及尿液AQP2的浓度,分析各组间血清AQP1及尿液AQP2的浓度变化。结果:1、高血压组与体检健康组比较,AQP1浓度降低、AQP2浓度增高,差异均具有统计学意义(P0.05)。2、罹患西北燥证的高血压组与未罹患西北燥证的高血压组比较,AQP1浓度降低差异具有统计学意义(P0.05),AQP2浓度差异无统计学意义。3、阴虚阳亢型高血压组与非阴虚阳亢型高血压组比较,AQP1浓度降低、AQP2浓度增高,差异均具有统计学意义(P0.05)。4、6组间血清AQP1浓度的两两比较结果:组6血清AQP1浓度明显高于其余5组,差异具有统计学意义(P0.05)。组4分别与组1、组2、组3、组5对比,血清AQP1浓度明显偏高,差异具有统计学意义(P0.05)。组1、组2、组3、组5之间的两两对比差异无统计学意义。5、6组间尿液AQP2浓度两两比较的结果:组1、组2、组3、组4分别与组5、组6对比,尿液AQP2浓度明显偏高,差异具有统计学意义(P0.05);组1、组2、组3之间相互对比,尿液AQP2浓度无统计学差异。6、血清AQP1浓度与尿液AQP2浓度呈负相关关系。结论:1、在高血压组中AQP1浓度降低、AQP2浓度升高,提示AQP1、AQP2可能参与高血压病的发生与发展。2、在高血压患者中罹患西北燥证组的AQP1浓度低于未罹患西北燥证组,在体检健康者中罹患西北燥证组的AQP1浓度低于未罹患西北组,提示人体内AQP1的低表达与西北燥证的发生有关。3、高血压阴虚阳亢组与高血压非阴虚阳亢组比较,AQP1浓度降低、AQP2浓度升高,提示AQP1浓度的减少、AQP2浓度的增加可能是阴虚阳亢型高血压的发生诱因与加重因素。4、尿液AQP2的浓度与高血压关系密切,与西北燥证的关系不大。
[Abstract]:Objective: to observe the changes of serum AQP1, urine AQP2 concentration in patients with hyperactivity of yang due to yin deficiency and patients with northwest dryness syndrome, and to explore the relationship between AQP1,AQP2 and hypertension in Xinjiang and the pathogenesis of northwest dryness syndrome. Methods: 120 patients with hypertension and 60 healthy persons were divided into 6 groups. Group 1 was hypertension with yin deficiency and yang hyperactivity, group 2 was hypertension without yin deficiency and yang hyperactivity, and group 3 was hypertension with yin deficiency and yang hyperactivity without northwest dryness syndrome. Group 4 was a non-yin deficiency hyperactivity type hypertension patient without northwest dryness syndrome, group 5 was a healthy person with northwest dryness syndrome, group 6 was a healthy person without northwest dryness syndrome. There are 30 people in each group. The blood and urine samples of all the subjects were collected. The serum AQP1 and urine AQP2 were detected by ELISA method. The changes of serum AQP1 and urine AQP2 were analyzed. Results: 1. The concentration of AQP1 and the concentration of AQP2 in hypertension group were lower than those in physical health group, the difference was statistically significant (P0.05). The difference between hypertension group with northwest dryness syndrome and hypertension group without northwest dryness syndrome was significant (P0.05). The decrease of AQP1 concentration was statistically significant (P0.05), but there was no significant difference in AQP2 concentration. 3. Compared with non-yin deficiency hyperactivity type hypertension group, AQP1 concentration decreased and AQP2 concentration increased in hyperactivity of yin deficiency and yang group. The difference was statistically significant (P0.05). 4The results of pairwise comparison of serum AQP1 concentration among 6 groups: the serum AQP1 concentration of group 6 was significantly higher than that of the other 5 groups, the difference was statistically significant (P0.05). Compared with group 1, group 2, group 3 and group 5, serum AQP1 concentration in group 4 was significantly higher than that in group 1, group 2, group 3 and group 5 (P0.05). There was no significant difference in urine AQP2 concentration between group 1, group 2, group 3 and group 5. The results of comparison of urine AQP2 concentration between group 1, group 2, group 3 and group 4 were significantly higher than those in group 5, group 1, group 2, group 3 and group 4, respectively. The difference was statistically significant (P0.05). There was no significant difference in urine AQP2 concentration between group 1, group 2 and group 3. 6. There was a negative correlation between serum AQP1 concentration and urine AQP2 concentration. Conclusion: 1. The concentration of AQP1 decreased and the concentration of AQP2 increased in hypertension group, suggesting that AQP1,AQP2 might be involved in the occurrence and development of hypertension. 2. The AQP1 concentration in patients with northwest dryness syndrome was lower than that in patients without northwest dryness syndrome. The concentration of AQP1 in the group with northwest dryness syndrome was lower than that in the group without northwest dryness, suggesting that the low expression of AQP1 in the human body was related to the occurrence of northwest dryness syndrome. 3. The concentration of AQP1 in hypertensives with yin deficiency and hyperactivity of yang was lower than that in the group without hyperactivity of yang due to deficiency of yin. The increase of AQP2 concentration suggests that the decrease of AQP1 concentration and the increase of AQP2 concentration may be the inducement and aggravation factor of hypertension with yin deficiency and yang hyperactivity. 4. The concentration of AQP2 in urine is closely related to hypertension, but not related to dryness syndrome in Northwest China.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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