温经通络汤联合针灸治疗风寒湿痹型关节炎的疗效及对患者血清Wnt-3α,β-catenin及BMP-2表达的影响

发布时间：2019-01-14 07:53

【摘要】：目的:探讨温经通络汤结合针灸治疗风寒湿痹型关节炎的疗效及对患者血清分泌型糖蛋白(Wnt)-3α,β-链蛋白(β-catenin)及骨形成蛋白-2(bone morphogenetic proteins-2,BMP-2)表达的影响。方法:选自天津中医药大学第一附属医院2015年2月—2016年11月收治的112例风寒湿痹型类风湿性关节炎(RA)患者,按照随机数字表将其分成观察组与对照组,每组56例。观察组给予温经通络汤联合针灸治疗,对照组给予塞来昔布联合来氟米特治疗,比较两组临床疗效、治疗前后中医临床证候积分、红细胞沉降率(erythrocyte sedimentation rate,ESR),C反应蛋白(C-reaction protein,CRP)及类风湿因子(rheumatoid factor,RF)变化情况以及血清Wnt-3α,β-catenin及BMP-2水平变化情况。结果:治疗后,观察组总有效率为94.64%,对照组总有效率为74.00%,观察组优于对照组(P0.01)。两组治疗后中医临床证候积分均较治疗前显著下降(P0.01),与对照组治疗后比较,观察组降低更显著(P0.01)。两组治疗后ESR,CRP,RF水平均较治疗前显著下降(P0.01),与对照组治疗后比较,观察组下降更显著(P0.05)。与治疗前比较,观察组治疗后血清Wnt-3α,β-catenin及BMP-2水平均显著下降(P0.01),对照组治疗前后比较无统计学差异。结论:温经通络汤结合针灸治疗风寒湿痹型关节炎疗效显著,其可下调Wnt-3α,β-catenin,BMP-2表达,缓解关节疼痛及改善关节功能。
[Abstract]:Objective: to investigate the therapeutic effect of Wenjing Tongluo decoction (WJT) combined with acupuncture and moxibustion on rheumatic dampness arthritic arthritis and its effect on serum secretory glycoprotein (Wnt) 3 伪, 尾 -chain protein (尾 catenin) and bone morphogenetic protein-2 (bone morphogenetic proteins-2, (BMP 2 (bone morphogenetic proteins-2,). BMP-2) expression. Methods: one hundred and twelve patients with rheumatoid arthritis (RA) were selected from the first affiliated Hospital of Tianjin University of traditional Chinese Medicine from February 2015 to November 2016. They were divided into observation group and control group according to the random number table, 56 cases in each group. The observation group was treated with Wenjing Tongluo decoction combined with acupuncture and moxibustion, while the control group was treated with celecoxib combined with leflunomide. C-reactive protein (C-reaction protein,CRP), rheumatoid factor (rheumatoid factor,RF) and serum Wnt-3 伪, 尾-catenin and BMP-2 levels were also changed. Results: after treatment, the total effective rate of the observation group was 94.64 and that of the control group was 74.00. The observation group was superior to the control group (P0.01). After treatment, the scores of TCM syndromes in both groups were significantly lower than those before treatment (P0.01). Compared with the control group, the scores of TCM syndromes in the observation group were significantly lower than those in the control group (P0.01). After treatment, ESR,CRP,RF levels in both groups were significantly lower than those before treatment (P0.01), compared with the control group after treatment, the observation group decreased more significantly (P0.05). The levels of serum Wnt-3 伪, 尾-catenin and BMP-2 in the observation group were significantly lower than those before and after treatment (P0.01), but there was no significant difference before and after treatment in the control group. Conclusion: Wenjing Tongluo decoction combined with acupuncture and moxibustion is effective in treating rheumatic dampness arthritic arthritis. It can down-regulate the expression of Wnt-3 伪, 尾-catenin,BMP-2, relieve joint pain and improve joint function.
【作者单位】： 天津中医药大学第一附属医院;
【基金】：天津市卫生局中医、中西医结合科研课题(07061)
【分类号】：R274.9

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