基于关联规则挖掘健脾类中药对骨关节炎患者免疫炎症指标的影响
发布时间：2019-01-17 12:48
【摘要】：目的应用关联规则和统计学方法分析导师刘健教授治疗骨关节炎所用健脾类中药对患者体内免疫炎症及代谢指标的影响,为优化处方提供依据。方法整理安徽中医药大学第一附属医院风湿免疫科2012年6月至2015年10月骨关节炎住院患者的病历资料。采用SPSS 22.0和SPSS Clementine 12.0软件Aprior模块分析健脾类中药与炎症免疫及代谢指标变化的关系。结果共有1414例骨关节炎患者。对其中药处方进行分析,以健脾类中药频率最高,前5位分别为茯苓、甘草、陈皮、山药、薏苡仁。设定最小置信度为75%,最小支持度为20%。经Aprior模块分析得出薏苡仁与茯苓关联于超氧化物歧化酶(SOD)指标上升(置信度88.06%,支持度32.05%),关联于超敏C反应蛋白(hs-CRP)指标下降(置信度84.03%,支持度23.29%),健脾药薏苡仁与活血药鸡血藤组合关联于ESR下降(置信度84.40%,支持度20.16%)。健脾药薏苡仁与祛风湿药宧莶草组合与补体C3、C4关联度最高;健脾药茯苓、甘草与川牛膝组合与IgA、IgG、IgM关联度最高。有薏苡仁组治疗后SOD明显升高,ESR、hs-CRP、IgG、补体C3、补体C4下降(P0.05或P0.01);与无薏苡仁组治疗后比较,有薏苡仁组在降低ESR、hs-CRP、补体C3方面优于无薏苡仁组,且能上提SOD水平(P0.05或P0.01)。与氨基葡萄糖组治疗后比较,有薏苡仁组在降低ESR、hs-CRP以及提高SOD水平上明显优于氨基葡萄糖组,且差异有统计学意义(P0.05或P0.01)。结论健脾类中药薏苡仁、茯苓和甘草与免疫炎症及代谢指标关联度较高,其中薏苡仁在降低ESR、hs-CRP以及提高SOD水平上起重要作用,其作用机制有待于进一步研究。
[Abstract]:Objective to analyze the effect of Chinese herbal medicine for strengthening spleen in patients with osteoarthritis treated by Professor Liu Jian by using association rules and statistical methods, so as to provide the basis for optimizing the prescription. Methods the medical records of patients with osteoarthritis from June 2012 to October 2015 in the Department of Rheumatology and Immunology of the first affiliated Hospital of Anhui University of traditional Chinese Medicine were analyzed. SPSS 22.0 and SPSS Clementine 12.0 software Aprior module were used to analyze the relationship between traditional Chinese medicine for invigorating spleen and the changes of inflammatory immunity and metabolic indexes. Results there were 1414 cases of osteoarthritis. The Chinese medicine prescription was analyzed, the frequency of Chinese medicine for strengthening spleen was the highest, the top five were Poria cocos, liquorice, old peel, yam and Coix seed respectively. Set minimum confidence to 75 and minimum support to 20. The results of Aprior module analysis showed that Coix seed and Poria cocos were associated with the increase of superoxide dismutase (SOD) index (confidence degree 88.06, support 32.05%), and the decrease of hs-CRP index (confidence degree 84.03%). The degree of support was 23.29%, and the combination of Coix seed and blood activating drug was associated with the decrease of ESR (confidence 84.40, support 20.16%). The combination of Coix seed and Herba Sesbeckiae had the highest correlation degree with complement C _ 3N _ 4, and the combination of poria cocos, liquorice and Achyranthes bidentata with IgA,IgG,IgM had the highest correlation degree. In Coix seed group, SOD increased significantly, ESR,hs-CRP,IgG, complement C3 and complement C4 decreased (P0.05 or P0.01). Compared with the group without Coix seed after treatment, the Coix seed group was superior to the Coix seed group in reducing the complement C3 of ESR,hs-CRP, and could raise the level of SOD (P0.05 or P0.01). Compared with the glucosamine group, the Coix seed group was superior to the glucosamine group in decreasing ESR,hs-CRP and increasing the level of SOD, and the difference was statistically significant (P0.05 or P0.01). Conclusion Coix seed, Poria cocos and Glycyrrhiza uralensis have high correlation with immune inflammation and metabolism. Coix seed plays an important role in decreasing ESR,hs-CRP and increasing SOD level, and its mechanism needs further study.
【作者单位】： 安徽中医药大学;
【基金】：国家临床重点专科中医风湿病科建设项目(No.财社[2013]239号) 国家中医药重点学科中医痹病学建设项目(No.国中医药发[2009内科应用]30号) 2016年中央引导地方科技发展专项(No.财教[2016]1188) 安徽省科技攻关项目(No.1301042211) 中医药行业科研专项(No.201307001) 现代中医内科应用基础与开发研究安徽省重点实验室(No.财教[2016]518) 2015年技术创新服务体系专项(No.[2015]1551)
【分类号】：R274.9
本文编号：2410078
[Abstract]:Objective to analyze the effect of Chinese herbal medicine for strengthening spleen in patients with osteoarthritis treated by Professor Liu Jian by using association rules and statistical methods, so as to provide the basis for optimizing the prescription. Methods the medical records of patients with osteoarthritis from June 2012 to October 2015 in the Department of Rheumatology and Immunology of the first affiliated Hospital of Anhui University of traditional Chinese Medicine were analyzed. SPSS 22.0 and SPSS Clementine 12.0 software Aprior module were used to analyze the relationship between traditional Chinese medicine for invigorating spleen and the changes of inflammatory immunity and metabolic indexes. Results there were 1414 cases of osteoarthritis. The Chinese medicine prescription was analyzed, the frequency of Chinese medicine for strengthening spleen was the highest, the top five were Poria cocos, liquorice, old peel, yam and Coix seed respectively. Set minimum confidence to 75 and minimum support to 20. The results of Aprior module analysis showed that Coix seed and Poria cocos were associated with the increase of superoxide dismutase (SOD) index (confidence degree 88.06, support 32.05%), and the decrease of hs-CRP index (confidence degree 84.03%). The degree of support was 23.29%, and the combination of Coix seed and blood activating drug was associated with the decrease of ESR (confidence 84.40, support 20.16%). The combination of Coix seed and Herba Sesbeckiae had the highest correlation degree with complement C _ 3N _ 4, and the combination of poria cocos, liquorice and Achyranthes bidentata with IgA,IgG,IgM had the highest correlation degree. In Coix seed group, SOD increased significantly, ESR,hs-CRP,IgG, complement C3 and complement C4 decreased (P0.05 or P0.01). Compared with the group without Coix seed after treatment, the Coix seed group was superior to the Coix seed group in reducing the complement C3 of ESR,hs-CRP, and could raise the level of SOD (P0.05 or P0.01). Compared with the glucosamine group, the Coix seed group was superior to the glucosamine group in decreasing ESR,hs-CRP and increasing the level of SOD, and the difference was statistically significant (P0.05 or P0.01). Conclusion Coix seed, Poria cocos and Glycyrrhiza uralensis have high correlation with immune inflammation and metabolism. Coix seed plays an important role in decreasing ESR,hs-CRP and increasing SOD level, and its mechanism needs further study.
【作者单位】： 安徽中医药大学;
【基金】：国家临床重点专科中医风湿病科建设项目(No.财社[2013]239号) 国家中医药重点学科中医痹病学建设项目(No.国中医药发[2009内科应用]30号) 2016年中央引导地方科技发展专项(No.财教[2016]1188) 安徽省科技攻关项目(No.1301042211) 中医药行业科研专项(No.201307001) 现代中医内科应用基础与开发研究安徽省重点实验室(No.财教[2016]518) 2015年技术创新服务体系专项(No.[2015]1551)
【分类号】：R274.9
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