心葆药食两用中药颗粒治疗冠心病心血瘀阻证的临床研究

发布时间：2019-01-25 18:55

【摘要】：目的观察心葆药食两用中药颗粒组方对冠心病心血瘀阻证患者血管内皮功能的作用。方法选取2015年1月至2016年1月入住郑州市中医院的有冠心病且辩证符合心血瘀阻证的患者200例,分为观察组(n=98)和对照组(n=102)。观察组给予心葆药食两用中药颗粒+常规药物,对照组给予常规药物。观察8周后,各组用酶联免疫吸附试验(ELISA)试剂盒测定内皮素(ET-1)、一氧化氮(NO)和血管紧张素Ⅱ(AngⅡ)的水平;观察两组血脂总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)及中医临床症候评分。结果对照组治疗后TC水平与治疗前比较下降,比较差异有统计学意义(P0.05);观察组治疗后TC、TG、LDL水平均低于治疗前,也低于对照组(P0.05)。治疗后,观察组NO、ET-1、AngⅡ、FMD水平与治疗前相比差异有统计学意义(P0.05)。观察组NO和FMD水平高于对照组,ET-1、Ang-Ⅱ水平低于对照组(P0.05)。治疗后,观察组中医临床症候各项评分指标均较治疗前降低(P0.05)。与对照组相比,观察组心悸、气短次数和临床症候总评分均较低(P0.05)。结论心葆药食两用中药颗粒可缓解冠心病心血瘀阻型患者的血管紧张,减轻其内皮细胞损伤,改善临床症状。
[Abstract]:Objective to observe the effect of Xinbao decoction on vascular endothelial function in patients with heart blood stasis syndrome. Methods from January 2015 to January 2016, 200 patients with coronary heart disease who were admitted to Zhengzhou traditional Chinese Medicine Hospital were divided into observation group (n = 98) and control group (n = 102). The observation group was treated with Xinbao medicine and food Chinese medicine granules, while the control group was given routine medicine. After 8 weeks, the levels of endothelin (ET-1), nitric oxide (NO) and angiotensin 鈪，

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