必利劲联合蚕茸柱天胶囊治疗肾气不固证早泄患者的疗效观察
发布时间：2019-02-09 15:46
【摘要】：目的：通过观察必利劲(盐酸达泊西汀片)联合蚕茸柱天胶囊治疗肾气不固证早泄患者的疗效,探讨中西结合治疗对于改善早泄患者症状以及提高生活质量的疗效。方法：根据研究设计选取符合纳入标准及排除标准的病例进行治疗及观察,所有患者均来自2015年3月至2015年12月于广州中医药大学第一附属医院泌尿外科男科门诊就诊的患者。被筛选的患者中,合格的有78例,经过随机数字表的查阅,患者被随机分入三组——治疗组、对照组A及对照组B,病例数均为26人。三个组均记录患者的年龄、CIPE-5评分(中国早泄患者性功能评价表)以及IELT(射精潜伏时间)所有的数据经统计学处理,组间的差异均无统计学意义(PO.05)。三组患者分别给予药物治疗,治疗方法如下：①治疗组：必利劲(30mg po性生活前2小时)十蚕茸柱天胶囊(2粒po bid 4周)；②对照组A：蚕茸柱天胶囊(2粒po bid 4周)③对照组B：必利劲(30mg po性生活前2小时)。患者在1个月后门诊复诊,了解病情及再次记录CIPE-5评分、记录IELT等。成果：门诊复诊的患者三组共有75例(三组均有1例脱失)均询问病史、记录CIPE-5评分、记录患者IELT。所有数据经统计学处理,①关于CIPE-5评分(分)：治疗组平均评分由治疗前的(10.54±2.70)提高到(21.28±5.84),对照组A平均评分由治疗前的(10.46±2.90)提高到(17.40±6.52),对照组B平均评分由治疗前的(10.62±2.82)提高到(17.20±6.34),组内比较三组均有统计学意义(P0.05),组间比较：治疗组与对照组A组间有统计学意义(P0.05),治疗组与对照组B组间有统计学意义(P0.05),对照组A与对照组B组间不存在统计学意义(P0.05)。②关于IELT(分)：治疗组平均时间由治疗前(0.95±0.40)延长至(3.16±1.13),对照组A平均时间由治疗前(1.00±0.40)延长至(2.43±1.24),对照组B平均时间由治疗前(0.97±0.40)延长至(2.33±1.22),组内比较三组均有统计学意义(P0.05),组间比较：治疗组与对照组A组间存在统计学意义(P0.05),治疗组与对照组B组间存在统计学意义(P0.05),对照组A与对照组B之间不存在统计学意义(P0.05)。③治疗后,治疗组有效率为88%,对照组A有效率为68%,对照组B有效率为64%,经比较,治疗组有效率高于对照组A和对照组B,差异有统计学意义(P0.05),而对照组A和对照组B的有效率无明显差异(P0.05)。结论：必利劲联合蚕茸柱天胶囊对于改善肾气不固证早泄患者症状比单一服用蚕茸柱天胶囊或者单一服用必利劲的疗效更加明显,有效率更高。中西医结合治疗早泄,优势明显,值得临床推广。
[Abstract]:Objective: to observe the curative effect of pirijin (dapoxetine hydrochloride) combined with silkworm antler Zhutian capsule in treating premature ejaculation with kidney qi deficiency syndrome, and to explore the effect of Chinese and western combination therapy on improving symptoms and quality of life of patients with premature ejaculation. Methods: according to the design of the study, the patients who met the criteria of inclusion and exclusion were selected for treatment and observation. All the patients were from the outpatient clinic of urology department of the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine from March 2015 to December 2015. Among the selected patients, 78 cases were qualified. The patients were randomly divided into three groups: treatment group, control group A and control group B, with 26 cases. All the data of age, CIPE-5 score (sexual function evaluation table) and IELT (ejaculation latency time) of the three groups were statistically analyzed. There was no significant difference between the three groups (PO.05). Three groups of patients were given drug treatment as follows: 1 treatment group: pirijin (2 hours before 30mg po sexual life) 10 silkworm antler column days capsule (2 po bid 4 weeks); 2control group A: silkworm antler column days capsule (2 po bid 4 weeks) 3 control group B: pirigin (2 hours before 30mg po sexual life). After one month, the patients were followed up in outpatient clinic to understand the condition and record the CIPE-5 score, IELT and so on. Results: 75 patients in all three groups were asked for medical history, CIPE-5 score was recorded and IELT. was recorded in all three groups. All the data were statistically processed, 1about the CIPE-5 score (score): the average score of the treatment group increased from (10.54 卤2.70) to (21.28 卤5.84), The average score of control group A increased from (10.46 卤2.90) to (17.40 卤6.52) before treatment, and that of control group B increased from (10.62 卤2.82) to (17.20 卤6.34). There were significant differences among the three groups (P0.05), between the treatment group and the control group A (P0.05), between the treatment group and the control group B (P0.05), between the treatment group and the control group B, there were significant differences between the treatment group and the control group (P0.05). There was no significant difference between control group A and control group B (P0.05). 2 about IELT (score): the average time of treatment group was prolonged from (0.95 卤0.40) to (3.16 卤1.13). The mean time of control group A was prolonged from (1.00 卤0.40) to (2.43 卤1.24), that of control group B was prolonged from (0.97 卤0.40) to (2.33 卤1.22). There were significant differences among the three groups (P0.05). The comparison between the treatment group and the control group A was statistically significant (P0.05), the treatment group and the control group B had statistical significance (P0.05). There was no significant difference between control group A and control group B (P0.05). 3 after treatment, the effective rate of treatment group was 88kum, the effective rate of control group A was 68, the effective rate of control group B was 64 cents. The effective rate of treatment group was higher than that of control group A and control group B, the difference was statistically significant (P0.05), while the effective rate of control group A and control group B had no significant difference (P0.05). Conclusion: the effect of pirijin combined with silkworm antler zhutian capsule on improving the symptoms of premature ejaculation patients with kidney qi is more obvious and the effective rate is higher than that of taking silkworm antler zhutian capsule alone or taking pirijin alone. The treatment of premature ejaculation with integrated Chinese and western medicine has obvious advantages and is worthy of clinical promotion.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
本文编号：2419115
[Abstract]:Objective: to observe the curative effect of pirijin (dapoxetine hydrochloride) combined with silkworm antler Zhutian capsule in treating premature ejaculation with kidney qi deficiency syndrome, and to explore the effect of Chinese and western combination therapy on improving symptoms and quality of life of patients with premature ejaculation. Methods: according to the design of the study, the patients who met the criteria of inclusion and exclusion were selected for treatment and observation. All the patients were from the outpatient clinic of urology department of the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine from March 2015 to December 2015. Among the selected patients, 78 cases were qualified. The patients were randomly divided into three groups: treatment group, control group A and control group B, with 26 cases. All the data of age, CIPE-5 score (sexual function evaluation table) and IELT (ejaculation latency time) of the three groups were statistically analyzed. There was no significant difference between the three groups (PO.05). Three groups of patients were given drug treatment as follows: 1 treatment group: pirijin (2 hours before 30mg po sexual life) 10 silkworm antler column days capsule (2 po bid 4 weeks); 2control group A: silkworm antler column days capsule (2 po bid 4 weeks) 3 control group B: pirigin (2 hours before 30mg po sexual life). After one month, the patients were followed up in outpatient clinic to understand the condition and record the CIPE-5 score, IELT and so on. Results: 75 patients in all three groups were asked for medical history, CIPE-5 score was recorded and IELT. was recorded in all three groups. All the data were statistically processed, 1about the CIPE-5 score (score): the average score of the treatment group increased from (10.54 卤2.70) to (21.28 卤5.84), The average score of control group A increased from (10.46 卤2.90) to (17.40 卤6.52) before treatment, and that of control group B increased from (10.62 卤2.82) to (17.20 卤6.34). There were significant differences among the three groups (P0.05), between the treatment group and the control group A (P0.05), between the treatment group and the control group B (P0.05), between the treatment group and the control group B, there were significant differences between the treatment group and the control group (P0.05). There was no significant difference between control group A and control group B (P0.05). 2 about IELT (score): the average time of treatment group was prolonged from (0.95 卤0.40) to (3.16 卤1.13). The mean time of control group A was prolonged from (1.00 卤0.40) to (2.43 卤1.24), that of control group B was prolonged from (0.97 卤0.40) to (2.33 卤1.22). There were significant differences among the three groups (P0.05). The comparison between the treatment group and the control group A was statistically significant (P0.05), the treatment group and the control group B had statistical significance (P0.05). There was no significant difference between control group A and control group B (P0.05). 3 after treatment, the effective rate of treatment group was 88kum, the effective rate of control group A was 68, the effective rate of control group B was 64 cents. The effective rate of treatment group was higher than that of control group A and control group B, the difference was statistically significant (P0.05), while the effective rate of control group A and control group B had no significant difference (P0.05). Conclusion: the effect of pirijin combined with silkworm antler zhutian capsule on improving the symptoms of premature ejaculation patients with kidney qi is more obvious and the effective rate is higher than that of taking silkworm antler zhutian capsule alone or taking pirijin alone. The treatment of premature ejaculation with integrated Chinese and western medicine has obvious advantages and is worthy of clinical promotion.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
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