散痹汤加减治疗类风湿关节炎肾虚寒湿证的临床研究
发布时间：2019-02-11 19:28
【摘要】：评价散痹汤加减治疗类风湿关节炎肾虚寒湿证的疗效及安全性。该试验将168例符合条件的受试者随机分为中药组、西药组和中西药组,每组各56例。分别给予散痹汤加减,甲氨蝶呤,散痹汤加减+甲氨蝶呤,疗程均为16周。观察各组治疗前后健康状况(HAQ)、疾病活动指数(DAS28)、视觉模拟评分(VAS)、中医证候、血沉(ESR)、C反应蛋白(CRP)、抗环瓜氨酸肽(CCP)和类风湿因子(RF)的变化。治疗后中西药组总有效率92.7%,优于中药组79.2%和西药组的82.4%(P0.05);中药组和西药组比较无明显差异,表明散痹汤加减治疗类风湿关节炎肾虚寒湿证具有有效性;中西药组和中药组中医证候评分较西药组改善更为明显(P0.05);其他症状中西药组改善均优于中药组和西药组(P0.05),中药组和西药组比较无明显差异,表明散痹汤加减可有效改善类风湿关节炎肾虚寒湿证的临床症状;不良反应的发生率中药组(3.8%,2/53)中西药组(16.4%,9/55)西药组(33.9%,18/53)(P0.05)。综合以上研究散痹汤加减治疗类风湿关节炎肾虚寒湿证的疗效与甲氨蝶呤无明显差异,具有有效性,且不良反应的发生率较甲氨蝶呤低;散痹汤加减结合甲氨蝶呤片治疗类风湿关节炎肾虚寒湿证具有协同增效的作用,且可降低甲氨蝶呤的不良反应。
[Abstract]:To evaluate the efficacy and safety of Sanbi decoction in treating rheumatoid arthritis with kidney deficiency and cold dampness syndrome. 168 eligible subjects were randomly divided into Chinese medicine group, western medicine group and western medicine group with 56 cases in each group. Sangbi decoction, methotrexate and Sangbi decoction were given methotrexate for 16 weeks. (HAQ), disease activity index (DAS28), visual analogue score (VAS), (ESR), C reactive protein (CRP), (ESR) and TCM syndromes were observed before and after treatment. Changes of anti-cyclic citrullinated peptide (CCP) and rheumatoid factor (RF). After treatment, the total effective rate of the Chinese and western medicine group was 92.7%, which was better than that of the traditional Chinese medicine group (79.2%) and the western medicine group (82.4%) (P0.05). There was no significant difference between the traditional Chinese medicine group and the western medicine group, which indicated that Sangbi decoction was effective in treating rheumatoid arthritis with kidney deficiency and cold dampness syndrome, and the TCM syndrome score of the traditional Chinese medicine group and the traditional Chinese medicine group was more improved than that of the western medicine group (P0.05). The improvement of other symptoms in traditional Chinese medicine group and western medicine group were better than that in traditional Chinese medicine group and western medicine group (P0.05). There was no significant difference between traditional Chinese medicine group and western medicine group, which indicated that Sangbi decoction could effectively improve the clinical symptoms of rheumatoid arthritis with kidney deficiency and cold dampness syndrome. The incidence of adverse drug reactions in the Chinese medicine group (3.8 / 53), the traditional Chinese medicine group (16.4 / 55) and the western medicine group (33.9 / 18 / 53) (P0.05). According to the above study, the curative effect of Sanbi decoction in treating rheumatoid arthritis with deficiency of kidney and cold and dampness was not significantly different from that of methotrexate, and the incidence of adverse reactions was lower than that of methotrexate. Sangbi decoction combined with methotrexate tablet has synergistic effect in treating rheumatoid arthritis with deficiency of kidney and cold and dampness, and can reduce the adverse reaction of methotrexate.
【作者单位】： 河南省中医院;郑州大学第二附属医院;
【基金】：河南省科技攻关项目(172102310322)
【分类号】：R259
，
本文编号：2420036
[Abstract]:To evaluate the efficacy and safety of Sanbi decoction in treating rheumatoid arthritis with kidney deficiency and cold dampness syndrome. 168 eligible subjects were randomly divided into Chinese medicine group, western medicine group and western medicine group with 56 cases in each group. Sangbi decoction, methotrexate and Sangbi decoction were given methotrexate for 16 weeks. (HAQ), disease activity index (DAS28), visual analogue score (VAS), (ESR), C reactive protein (CRP), (ESR) and TCM syndromes were observed before and after treatment. Changes of anti-cyclic citrullinated peptide (CCP) and rheumatoid factor (RF). After treatment, the total effective rate of the Chinese and western medicine group was 92.7%, which was better than that of the traditional Chinese medicine group (79.2%) and the western medicine group (82.4%) (P0.05). There was no significant difference between the traditional Chinese medicine group and the western medicine group, which indicated that Sangbi decoction was effective in treating rheumatoid arthritis with kidney deficiency and cold dampness syndrome, and the TCM syndrome score of the traditional Chinese medicine group and the traditional Chinese medicine group was more improved than that of the western medicine group (P0.05). The improvement of other symptoms in traditional Chinese medicine group and western medicine group were better than that in traditional Chinese medicine group and western medicine group (P0.05). There was no significant difference between traditional Chinese medicine group and western medicine group, which indicated that Sangbi decoction could effectively improve the clinical symptoms of rheumatoid arthritis with kidney deficiency and cold dampness syndrome. The incidence of adverse drug reactions in the Chinese medicine group (3.8 / 53), the traditional Chinese medicine group (16.4 / 55) and the western medicine group (33.9 / 18 / 53) (P0.05). According to the above study, the curative effect of Sanbi decoction in treating rheumatoid arthritis with deficiency of kidney and cold and dampness was not significantly different from that of methotrexate, and the incidence of adverse reactions was lower than that of methotrexate. Sangbi decoction combined with methotrexate tablet has synergistic effect in treating rheumatoid arthritis with deficiency of kidney and cold and dampness, and can reduce the adverse reaction of methotrexate.
【作者单位】： 河南省中医院;郑州大学第二附属医院;
【基金】：河南省科技攻关项目(172102310322)
【分类号】：R259
，
本文编号：2420036
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