从寒湿毒论治慢性萎缩性胃炎癌前病变的临床观察

发布时间：2019-03-02 13:26

【摘要】：目的:从寒湿毒论治慢性萎缩性胃炎癌前病变患者,观察温中化湿解毒汤对患者的主要症状、体征和胃黏膜萎缩、肠上皮化生(IM)和异型增生(Dys)的影响,在治疗结束后6个月随访疾病复发情况。方法:将符合纳入标准的80例患者,采取随机法分为观察组和对照组各40例,对照组给予胃复春片口服,观察组给予中药温中化湿解毒汤加减治疗,两组均连续治疗26周,统计分析疗效。结果:治疗后观察组在临床疗效方面(总有效率92.50%)优于对照组(总有效率70.00%)(P0.05),治疗后观察组在胃脘胀痛、喜按喜暖、大便溏薄、气短乏力、纳差等方面的临床治愈率较对照组明显改善(P0.05),治疗后6个月观察组患者胃黏膜萎缩、IM较对照组好转(P0.05),两组患者Dys无明显变化。结论:温中化湿解毒汤能较好地改善脾胃虚寒(弱)证CAG患者的主要症状、体征,使胃黏膜萎缩、IM好转或部分恢复正常,复发率降低。
[Abstract]:Objective: to observe the effect of Wenzhong Huashi jiedu decoction on the main symptoms, signs, atrophy of gastric mucosa, intestinal metaplasia (IM) and dysplasia (Dys) in patients with chronic atrophic gastritis treated with cold-dampness toxin. The recurrence of the disease was followed up 6 months after treatment. Methods: 80 patients who met the inclusion criteria were randomly divided into observation group (n = 40) and control group (n = 40). The control group was given oral Weifuchun tablet and the observation group was treated with Wenzhong Huashi jiedu decoction for 26 weeks. Statistical analysis of curative effect. Results: the clinical efficacy (total effective rate 92.50%) in the observation group was better than that in the control group (70.00%) (P0.05). After 6 months treatment, the gastric mucosa atrophy and IM in the observation group were better than those in the control group (P0.05). There was no significant change in the Dys between the two groups. Conclusion: Wenzhong Huayi jiedu decoction can improve the main symptoms and signs of CAG patients with spleen-stomach deficiency and cold (weak) syndrome, make the gastric mucosa atrophy, improve or partly return to normal IM, and decrease the recurrence rate.
【作者单位】：上海市浦东新区周浦医院中医科;江苏省中医院;
【基金】：上海市浦东新区传统型中医临床示范学科建设资助项目(PDZYXK-3-2013008) 周浦医院重点学科建设资助项目(ZP-XK-2015B-5)
【分类号】：R259

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