健脾益肾化瘀方治疗精索静脉曲张所致弱精子症（脾肾阳虚型）的临床观察

发布时间：2019-03-03 18:39

【摘要】：目的:通过临床观察健脾益肾化瘀方对精索静脉曲张所致弱精子症(脾肾阳虚型)精液质量的影响,证明该方治疗本病的疗效和优势,并探讨其治疗机理。方法:研究对象选自2014年2月—2015年12月于焦作市中医院治疗的精索静脉曲张所致弱精子症(脾肾虚弱型)患者80例,年龄分布在22—45岁,符合精索静脉曲张不育症的诊断标准,按就诊先后顺序采用随机数字表法随机(1:1)均分为治疗组和对照组,每组各40例,分别给予健脾益肾化瘀方汤药和左卡尼汀口服液口服,1月为一疗程,分别对比两组患者服药三个疗程的精液分析结果(精子总数、精子浓度、精子总活率、前向运动精子百分率、正常精子百分率)。结果:1、治疗前治两组患者在年龄、静脉曲张度比较具有可比性2、治疗前后两组治疗有效率、精液质量(精子总数、精子浓度、精子总活率、前向运动精子百分率、正常形态精子百分率)比较,各组差异均具有统计学意义(均P0.05)。结论:对于精索静脉曲张所致弱精子症(脾肾阳虚型),健脾益肾化瘀方相对于左卡尼汀口服液治疗本病能显著提高患者精子质量,由此证实,该方是治疗精索静脉曲张所致弱精子症(脾肾阳虚型)的有效组方。2、通过本次研究证实,健脾益肾化瘀方改善VC所致弱精子症(脾肾阳虚型)患者的精子质量的机制,可能在于健脾益肾化瘀方能改善睾丸、附睾的生精、贮精、精子成熟的能力,并通过改善睾丸血供,减少睾丸及精索静脉内毒物蓄积及细胞凋亡,从而确保精子正常功能不被破坏,最终提高生育能力。
[Abstract]:Aim: to observe the effect of Jianpi Yishen Huayu recipe on semen quality of asthenospermia caused by varicocele (spleen-kidney yang deficiency type), and to prove its curative effect and advantage, and to explore its therapeutic mechanism. Methods: from February 2014 to December 2015, 80 patients with asthenospermia caused by varicocele (spleen and kidney deficiency type) were selected from Jiaozuo traditional Chinese Medicine Hospital. According to the diagnostic criteria of varicocele infertility, 40 cases in each group were randomly divided into treatment group (n = 40) and control group (n = 40) according to the order of treatment by random numerical table (1:1). Two groups of patients were treated with Jianpi Yishen Huayu decoction and levocarnitine oral liquid orally for 1 month. The results of semen analysis (total sperm count, sperm concentration, total sperm viability) were compared between the two groups after three courses of treatment. Percentage of forward-moving sperm, percentage of normal sperm). Results: 1. The two groups were comparable in age and venous curvature before and after treatment. Before and after treatment, the effective rate of treatment, semen quality (total sperm count, sperm concentration, total sperm viability, percentage of forward motility sperm) were compared between the two groups. Normal morphology sperm percentage), the differences were statistically significant (all P0.05). Conclusion: for asthenospermia caused by varicocele (spleen-kidney yang deficiency type), Jianpi Yishen Huayu recipe can significantly improve the sperm quality of patients with this disease compared with levocarnitine oral liquid, which proves that Jianpi Yishen Huayu recipe can significantly improve the sperm quality of the patients. This prescription is an effective prescription for the treatment of asthenospermia caused by varicocele (spleen-kidney yang deficiency type). 2. Through this study, it is confirmed that Jianpi Yishen Huayu recipe can improve the sperm quality of patients with VC-induced asthenospermia (spleen-kidney yang deficiency type). It may be that Jianpi Yishen Huayu recipe can improve the ability of spermatogenesis, sperm storage and sperm maturation in testis and epididymis, and reduce the accumulation of toxins and apoptosis in testis and spermatic vein by improving testicular blood supply. This ensures that the normal function of sperm is not destroyed and ultimately improves fertility.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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