黄芪注射液对慢性心力衰竭疗效及对MDA、HO-1、NO的影响

发布时间：2019-03-14 10:43

【摘要】：目的:观察黄芪注射液治疗慢性心力衰竭(CHF)患者的作用,并探讨其对丙二醛(MDA)、血红素加氧酶1(HO-1)、血管舒张因子(NO)的影响。方法:将60例CHF患者随机分为黄芪注射液组和对照组各30例。对照组常规使用吸氧、利尿、扩血管、强心,控制原发病和消除心衰诱因等常规治疗。黄芪注射液组在常规治疗的基础上,应用黄芪注射液治疗。观察临床疗效,测定左室功能指标。并检测两组治疗前后MDA、HO-1、NO的浓度。结果:黄芪注射液组总有效率达到93.33%,显著高于对照组的76.67%(P0.05)。治疗前的6 min步行距离无明显差距,治疗后黄芪注射液组6 min步行距离是(693.83±23.70),显著高于对照组的(617.60±38.95)。治疗前的两组心功能参数差异无显著性,两组每搏出量(SV)、射血分数(EF)治疗后都显著增加(P0.05);治疗后黄芪注射液组SV、EF显著高于治疗后对照组(P0.05)。治疗前的两组MDA、NO、HO-1差异无显著性。与相应组的治疗前比较,治疗后两组MDA显著降低,NO与HO-1显著增加(P0.05);治疗后黄芪注射液组MDA低于治疗后对照组,NO、HO-1高于治疗后对照组,差异具有统计学意义(P0.05)。结论:黄芪注射液对CHF患者的心功能指标有明显改善作用,可能与其提高内源性抗氧化应激从而治疗CHF有关。
[Abstract]:Objective: To observe the effect of Huangjing injection on the treatment of chronic heart failure (CHF), and to explore its effect on malondialdehyde (MDA), heme oxygenase 1 (HO-1) and vasodilation factor (NO). Methods:60 patients with CHF were randomly divided into two groups: the Huanglian injection group and the control group. The normal use of oxygen inhalation, diuresis, vasodilator, strong heart, control of the original disease, and the elimination of the cause of heart failure were routinely used in the control group. On the basis of routine treatment, the Huangqi injection group is used for the treatment of the Huangyan injection. The clinical curative effect was observed and the left ventricular function index was determined. The concentrations of MDA, HO-1 and NO were measured before and after treatment. Results: The total effective rate of the injection group was 93.33%, which was significantly higher than that of the control group (76.67% (P0.05). There was no significant difference in the walking distance of 6 min before treatment, and the walking distance of 6 min after treatment was (693.83-23.70), which was significantly higher than that of the control group (617.60-38.95). There was no significant difference between the two groups of cardiac function before and after the treatment. There was a significant increase in the ejection fraction (SV) and the ejection fraction (EF) of the two groups (P0.05). The SV and EF of the injection group after treatment were significantly higher than those in the control group after treatment (P0.05). There was no significant difference between the two groups of MDA, NO and HO-1 before treatment. Compared with the treatment of the corresponding group, the MDA in the two groups was significantly decreased, and no significant increase in NO and HO-1 (P0.05). The MDA in the post-treatment group was lower than that of the control group after treatment, and the difference of NO and HO-1 was higher than that of the control group after treatment (P0.05). Conclusion: The index of cardiac function in patients with CHF may be significantly improved, and it may be related to the improvement of endogenous anti-oxidative stress in the treatment of CHF.
【作者单位】：南京中医药大学附属医院胸心外科;南京中医药大学附属医院科技处;
【基金】：国家自然科学基金项目(81573908)
【分类号】：R259

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