弃杖胶囊治疗肾虚血瘀型股骨头缺血性坏死的临床观察
发布时间：2019-03-18 20:00
【摘要】：目的通过对弃杖胶囊治疗肾虚血瘀型股骨头缺血性坏死的患者进行临床相关研究,证明弃杖胶囊对肾虚血瘀型股骨头缺血性坏死患者临床上治疗有效。方法根据该课题的相关纳入标准,收集筛选在2014年6月-2015年12月期间就诊于黑龙江省中医医院骨伤科,由骨伤科中医专家滕义和教授门诊接诊的股骨头缺血性坏死的患者,初诊患者总计160例,其中106例符合,按照随机数字表和患者先后就诊时间分为治疗组和对照组,每组53例包含着(ARCO I期、II期、IIIA期),中医辨证是肾虚血瘀型,其中治疗组患者服用弃杖胶囊,对照组患者服用仙灵骨葆胶囊,年龄选取在35-55岁,男女均可入组,使其除在分组不同外,其余均无显著性差异(包括性别,年龄,体重,基础疾病等方面)。观察两组用药3个月之后,记录治疗组和对照组的患者疼痛VAS评分和Harris髋关节功能评分以及MRI坏死指数三个指标相关数据。根据两组数据进行统计学分析P0.05,评价弃杖胶囊对肾虚血瘀型股骨头缺血性坏死的疗效,进而总结对比分析来揭露补肾祛瘀接骨法对治疗股骨头缺血性坏死疾病存在的机理。对入组的两组患者疼痛VAS评分和Harris髋关节功能评分以及MRI坏死指数进行收集记录,再建立数据库,应用SPSS17.0forwindows统计软件,计量资料采用均数±标准差(x±s)表示,多组数据使用单因素方差分析方法(F检验)。结果治疗结束后,两组患者疼痛VAS评分、Harris髋关节功能评分、MRI坏死指数与治疗前进行组内比较,三项指标均有统计学意义(P0.05)。治疗后的组间比较,疼痛VAS评分、MRI坏死指数具有统计学意义(P0.05),而Harris髋关节功能评分没有统计学意义(P0.05),提示治疗组改善疼痛和减少坏死体积优于对照组,而在改善Harris髋关节功能两组差异不显著,两组在治疗前后股骨头坏死的分期上没有显著性差异(即P0.05),提示两组对患者影像学分期没有明显治疗意义。治疗组显效9例、有效30例、无效11例,有效率78%;而对照组显效7例、有效27例、无效16例,有效率68%,提示治疗组有效率高于对照组。结论1.弃杖胶囊对肾虚血瘀型股骨头缺血性坏死临床治疗改善疼痛评分有效。2.弃杖胶囊在改善肾虚血瘀型股骨头缺血性坏死Harris髋关节功能评分有效。3.弃杖胶囊治疗前后影像学分期上没有明显效果,而仅仅在减少坏死体积上有治疗意义。
[Abstract]:Aim to study the clinical effect of Juzhu capsule on avascular necrosis of femoral head of kidney deficiency and blood stasis type, and to prove that it is effective in treating avascular necrosis of femoral head of kidney deficiency and blood stasis type. Methods according to the inclusion criteria of the subject, the patients with avascular necrosis of the femoral head who were treated in the Department of Orthopaedics of Heilongjiang Province traditional Chinese Medicine Hospital from June 2014 to December 2015 were collected and selected. The patients were divided into treatment group and control group according to the random number table and the time of visit, 53 cases in each group included (ARCO I stage, II stage, IIIA stage). The syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the patients were divided into treatment group and control group according to the random number table. The patients in the treatment group and the control group took Xianling Gubao capsule. The age was 35 years old and 55 years old. Both men and women could be admitted into the group, so that there was no significant difference (including sex, age, weight, etc.), except in the different groups, the other groups had no significant difference (including sex, age, body weight). Basic diseases, etc.) The pain VAS score, Harris hip function score and MRI necrosis index were recorded in the treatment group and the control group 3 months after the treatment of the treatment group and the control group. 3 months later, the pain score, the hip joint function score and the MRI necrosis index were recorded. According to the data of the two groups, a statistical analysis of P0.05 was carried out to evaluate the curative effect of abandoned stick capsule on avascular necrosis of the femoral head of kidney deficiency and blood stasis type. The mechanism of the treatment of avascular necrosis of femoral head by tonifying the kidney and removing blood stasis and connecting bone was revealed. The pain VAS score, Harris hip function score and MRI necrosis index were collected and recorded in the two groups. Then a database was established. The data were expressed by mean 卤standard deviation (xtable s) using SPSS17.0forwindows statistical software. One-way variance analysis (F-test) was used for multiple sets of data. Results after treatment, the pain VAS score, Harris hip function score and MRI necrosis index were significantly different between the two groups before and after treatment (P0.05). After treatment, the pain VAS score and MRI necrosis index had statistical significance (P0.05), but the Harris hip function score had no statistical significance (P0.05), suggesting that the treatment group was better than the control group in improving pain and reducing necrosis volume. However, there was no significant difference between the two groups in improving the hip function of Harris, and there was no significant difference in the stage of femoral head necrosis before and after treatment between the two groups (P0.05), suggesting that the two groups had no significant therapeutic significance in the imaging stage of the patients. In the treatment group, 9 cases were effective, 30 cases were effective, 11 cases were ineffective, and the effective rate was 78%, while that in the control group was 7 cases, 27 cases and 16 cases, and the effective rate was 68%, which indicated that the effective rate in the treatment group was higher than that in the control group. Conclusion 1. The clinical treatment of avascular necrosis of femoral head with kidney deficiency and blood stasis type is effective in improving pain score. 2. It is effective in improving Harris hip function score of avascular necrosis of femoral head with kidney deficiency and blood stasis type. 3. It has no obvious effect on imaging stages before and after treatment, but only has therapeutic significance in reducing necrotic volume.
【学位授予单位】：黑龙江省中医药科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9
，
本文编号：2443186
[Abstract]:Aim to study the clinical effect of Juzhu capsule on avascular necrosis of femoral head of kidney deficiency and blood stasis type, and to prove that it is effective in treating avascular necrosis of femoral head of kidney deficiency and blood stasis type. Methods according to the inclusion criteria of the subject, the patients with avascular necrosis of the femoral head who were treated in the Department of Orthopaedics of Heilongjiang Province traditional Chinese Medicine Hospital from June 2014 to December 2015 were collected and selected. The patients were divided into treatment group and control group according to the random number table and the time of visit, 53 cases in each group included (ARCO I stage, II stage, IIIA stage). The syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the syndrome differentiation of TCM was kidney deficiency and blood stasis type, and the patients were divided into treatment group and control group according to the random number table. The patients in the treatment group and the control group took Xianling Gubao capsule. The age was 35 years old and 55 years old. Both men and women could be admitted into the group, so that there was no significant difference (including sex, age, weight, etc.), except in the different groups, the other groups had no significant difference (including sex, age, body weight). Basic diseases, etc.) The pain VAS score, Harris hip function score and MRI necrosis index were recorded in the treatment group and the control group 3 months after the treatment of the treatment group and the control group. 3 months later, the pain score, the hip joint function score and the MRI necrosis index were recorded. According to the data of the two groups, a statistical analysis of P0.05 was carried out to evaluate the curative effect of abandoned stick capsule on avascular necrosis of the femoral head of kidney deficiency and blood stasis type. The mechanism of the treatment of avascular necrosis of femoral head by tonifying the kidney and removing blood stasis and connecting bone was revealed. The pain VAS score, Harris hip function score and MRI necrosis index were collected and recorded in the two groups. Then a database was established. The data were expressed by mean 卤standard deviation (xtable s) using SPSS17.0forwindows statistical software. One-way variance analysis (F-test) was used for multiple sets of data. Results after treatment, the pain VAS score, Harris hip function score and MRI necrosis index were significantly different between the two groups before and after treatment (P0.05). After treatment, the pain VAS score and MRI necrosis index had statistical significance (P0.05), but the Harris hip function score had no statistical significance (P0.05), suggesting that the treatment group was better than the control group in improving pain and reducing necrosis volume. However, there was no significant difference between the two groups in improving the hip function of Harris, and there was no significant difference in the stage of femoral head necrosis before and after treatment between the two groups (P0.05), suggesting that the two groups had no significant therapeutic significance in the imaging stage of the patients. In the treatment group, 9 cases were effective, 30 cases were effective, 11 cases were ineffective, and the effective rate was 78%, while that in the control group was 7 cases, 27 cases and 16 cases, and the effective rate was 68%, which indicated that the effective rate in the treatment group was higher than that in the control group. Conclusion 1. The clinical treatment of avascular necrosis of femoral head with kidney deficiency and blood stasis type is effective in improving pain score. 2. It is effective in improving Harris hip function score of avascular necrosis of femoral head with kidney deficiency and blood stasis type. 3. It has no obvious effect on imaging stages before and after treatment, but only has therapeutic significance in reducing necrotic volume.
【学位授予单位】：黑龙江省中医药科学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9
，
本文编号：2443186
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