喉源性咳嗽发病影响因素的初步调查研究

发布时间：2019-03-19 09:19

【摘要】：目的:对喉源性咳嗽的患者进行发病影响因素的初步调查研究,为今后喉源性咳嗽流行病学大样本研究及临床更好地防治喉源性咳嗽提供参考依据。方法:选择符合喉源性咳嗽诊断标准的患者200例作实验组,正常人100例作对照组,通过病史、临床症状体征的数据采集、外周血常规、纤维鼻咽喉镜检查、胸部X线片检查、C-反应蛋白及吸入性变应原筛查等指标的检测,填写调查问卷表,建立数据库,懫用SPSS19.0统计软件进行所有资料的统计学分析,得出结论。结果:1.在200例实验组中,男性92例(46%),女性108例(54%)。年龄40岁患者104例(52%),年龄≥40岁患者96例(48%),嗜烟酒者32例(16%),因受凉诱发者132例(66%),因感冒诱发者86例(43%),因过度劳累诱发者95例(47.5%),因食辛辣刺激食物导致者82例(41%),尘螨过敏所致者116例(58%)。在100例对照组中,男性56例(56%),女性44例(44%)。年龄40岁者54例(54%),年龄≥40岁者46例(46%),嗜烟酒者13例(13%),近一个月有受凉病史者8例(8%),有感冒病史者10例(10%),有过度劳累者12例(12%),喜食辛辣刺激食物者13例(13%),尘螨过敏者14例(14%)。通过采用二分类非条件Logistic回归进行单因素分析,结果显示:受凉、感冒、过度劳累、喜食刺激辛辣食物、尘螨过敏经比较差异有统计学意义(P0.05),说明受凉、感冒、过度劳累、喜食辛辣刺激食物、尘螨过敏可能是喉源性咳嗽患病的影响因素。然后将受凉、感冒、过度劳累、喜食辛辣刺激食物、尘螨过敏等可能影响因素进行二分类非条件Logistic回归多因素分析,结果同样显示:受凉、感冒、过度劳累、喜食辛辣刺激食物、尘螨过敏与喉源性咳嗽的发病有相关性,且从回归系数上看,与喉源性咳嗽的发病均呈正相关。2.在喉源性咳嗽发病影响因素的初步调查研究过程中,随机选择88名患者进行血清肺炎支原体抗体检测,结果无意中发现有41名患者呈阳性反应,阳性率达46.59%。随后在正常人中随机选择25人作对照组进行血清肺炎支原体抗体检测,检出率为8%。且经统计学分析,结果显示:肺炎支原体因素经比较差异有统计学意义(P0.05),证实了喉源性咳嗽的发病与肺炎支原体感染有一定的相关性。结论:在此次喉源性咳嗽发病影响因素的初步调查研究中发现受凉、感冒、过度劳累、喜食辛辣刺激食物、尘螨过敏、肺炎支原体感染等因素,皆可诱发喉源性咳嗽病,差异显著;而性别、年龄与喉源性咳嗽发病无关,吸烟或饮酒等因素与喉源性咳嗽发病也无明显相关性。因此,在临床卫生宣教工作中须鼓励大家尽可能避开影响因素,降低喉源性咳嗽之发病率及缩短喉源性咳嗽之疗程。
[Abstract]:Aim: to investigate the influential factors of laryngeal cough in patients with laryngogenic cough, and to provide reference basis for future epidemiological large samples of laryngeal cough and clinical prevention and treatment of laryngogenic cough. Methods: 200 patients who met the diagnostic criteria of laryngogenic cough were selected as experimental group and 100 normal persons as control group. The data collection of clinical symptoms and signs, peripheral blood routine examination, fibernasopharyngoscope and chest X-ray examination were carried out through medical history, clinical symptoms and signs, routine examination of peripheral blood. C-reactive protein and inhalant allergen screening were tested, questionnaire forms were filled out, database was established, and all data were analyzed by SPSS19.0 statistical software, and conclusions were drawn. Results: 1. Of the 200 cases, 92 (46%) were male and 108 (54%) were female. 104 cases (52%) were 40 years old, 96 cases (48%) were over 40 years old, 32 cases (16%) were smoking and drinking, 132 cases (66%) were induced by cold, 86 cases (43%) were caused by cold. 95 cases (47.5%) were induced by overwork, 82 cases (41%) were caused by spicy food, 116 cases (58%) were caused by dust mite allergy. In 100 cases of control group, 56 cases (56%) were male and 44 cases (44%) were female. 54 cases (54%) were 40 years old, 46 cases (46%) were over 40 years old, 13 cases (13%) were smoking and drinking, 8 cases (8%) had history of cold in the last month, 10 cases (10%) had history of cold. There were 12 cases (12%) with overwork, 13 cases (13%) with acrid food stimulation and 14 cases (14%) with allergies to dust mites. Single factor analysis was carried out by using two classification non-conditional Logistic regression. The results showed that cold, overwork, preference to eat stimulating spicy food, dust mite allergy were statistically significant (P0.05), indicating that cold, cold. Overwork, love to eat spicy food, dust mite allergy may be a risk factor for laryngogenic cough. Then the factors such as cold, overwork, food stimulation, dust mite allergy and so on were analyzed by Logistic regression. The results also showed that cold, overwork, and so on, could affect the factors of cold, overwork, and so on, and the results were as follows: cold, overwork, and so on. There was a positive correlation between allergies of dust mites and laryngogenic cough, and the regression coefficient showed that there was a positive correlation between allergies of dust mites and laryngogenic cough. 2. In the course of preliminary investigation on the influencing factors of laryngeal cough, 88 patients were randomly selected for detection of mycoplasma pneumoniae antibody in serum. The results showed that 41 patients showed positive reaction, the positive rate was 46.59%. Then 25 healthy subjects were randomly selected as control group for detection of mycoplasma pneumoniae antibody, the detection rate was 8%. By statistical analysis, the results showed that the mycoplasma pneumoniae factors were significantly different (P0.05), which confirmed that the incidence of laryngogenic cough and Mycoplasma pneumoniae infection had a certain correlation. Conclusion: in the preliminary investigation of the influencing factors of laryngeal cough, it was found that cold, overwork, food stimulation, dust mite allergy, mycoplasma pneumoniae infection and other factors could induce laryngogenic cough, and that the disease was caused by cold, overwork, acrid food, dust mite allergy, mycoplasma pneumoniae infection, and so on. The difference was significant. There was no significant correlation between sex, age and laryngogenic cough. Smoking or drinking had no significant correlation with laryngogenic cough. Therefore, people should be encouraged to avoid the influence factors, reduce the incidence of laryngogenic cough and shorten the course of treatment of laryngogenic cough.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R276.1

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