复方丹参滴丸在治疗冠心病及改善血清炎症因子水平中的应用价值

发布时间：2019-03-28 08:34

【摘要】：目的探讨复方丹参滴丸在治疗冠心病及改善血清炎症因子水平中的应用价值。方法 83例老年冠心病患者根据不同的治疗方法分为研究组41例和常规组41例,常规组给予氯吡格雷治疗,1次/d,75 mg/次。研究组在常规组的基础上加用复方丹参滴丸,口服3次/d,口服10丸/次,两组疗程均为3个月,比较两组治疗前后血清炎症因子白细胞介素(IL)-6和IL-10以及肱动脉血流介导性舒张(FMD)、内皮素(ET)、一氧化氮(NO)水平的变化。结果经过治疗,两组均取得较好的疗效,其中研究组临床总有效率和心电图改善的总有效率均高于对照组(P0.05)。两组血清IL-6水平显著降低,且研究组低于常规组,IL-10水平上升幅度均较同时期的常规组低(P0.05)。治疗3个月后,研究组FMD和NO水平均高于常规组(P0.05),ET水平低于常规组低(P0.05)。结论复方丹参滴丸治疗冠心病的效果较好,能有效改善炎症因子水平,改善或缓解老年冠心病病症。
[Abstract]:Objective to explore the application value of compound salvia miltiorrhiza dropping pill in treating coronary heart disease and improving the level of serum inflammatory factors. Methods 83 elderly patients with coronary heart disease were divided into study group (n = 41) and routine group (n = 41) according to different treatment methods. Clopidogrel was given once a day for 75 mg/ in the routine group. The study group was given compound salvia miltiorrhiza dropping pill 3 times a day and 10 pills a time on the basis of routine group. The course of treatment in both groups was 3 months. The changes of serum interleukin-6 (IL-6), interleukin-6 (IL-10) and brachial artery flow-mediated vasodilation (FMD),-et-(ET),) levels of nitric oxide (NO) were compared between the two groups before and after Results after treatment, the two groups achieved better curative effect, in which the total clinical effective rate and the total effective rate of ECG improvement in the study group were higher than those in the control group (P0.05). The serum IL-6 level in the two groups was significantly lower than that in the control group, and the level of IL-10 in the study group was lower than that in the routine group at the same time (P0.05). After 3 months of treatment, the levels of FMD and NO in the study group were higher than those in the routine group (P0.05), ET level was lower than that in the routine group) (P0.05). Conclusion the compound salvia miltiorrhiza dropping pill is effective in the treatment of coronary heart disease, and can effectively improve the level of inflammatory factors and improve or relieve the disease of coronary heart disease in the elderly.
【作者单位】：海南省中医院中医内科;杭州师范大学附属医院;
【分类号】：R259

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