祛痰活血颗粒治疗非酒精性脂肪性肝炎痰瘀互结证临床疗效评价

发布时间：2019-04-03 11:38

【摘要】：目的:通过观察中药祛痰活血颗粒对痰瘀互结证非酒精性脂肪性肝炎(NASH)患者治疗前后体重指数、肝功、血脂、症状、腹部B超的变化,评估祛痰活血颗粒治疗非酒精性脂肪性肝炎痰瘀互结证临床疗效。方法:将66例痰瘀互结证NASH患者被随机分为治疗组和对照组,治疗组服用祛痰活血颗粒,对照组服用多烯磷脂酰胆碱胶囊;治疗3月后,分别比较两组治疗前后体重指数、症状、肝功(ALT、AST、GGT)、血脂(TG、TC、HDL-C)及腹部B超变化。结果:(1)两组患者基线数据无差异,具有可比性。安全性指标未见异常(P0.05)。(2)两组观察指标中体重指数、中医症状积分、肝功、血脂在治疗后与治疗前比较都存在差异(P0.05),有统计学意义,具有较好的治疗效果;治疗后两组组间对比无差异(P0.05)。(3)两组观察指标中腹部B超治疗前后差异不明显(P0.05),两组治疗后组间对比无明显差异(P0.05)。结论:(1)祛痰活血颗粒治疗痰瘀互结证NASH能够降低体重指数、改善临床症状、改善肝功、血脂指标,尤其对症状(胁痛、胁胀、腹胀等)改善明显。(2)祛痰活血颗粒治疗痰瘀互结证NASH总体疗效方面优于多烯磷脂酰胆碱胶囊组。(3)祛痰活血颗粒治疗痰瘀互结证NASH对腹部B超影像学改变影响不大。(4)祛痰活血颗粒辨证运用中药制剂,配伍合理,不仅疗效显著,而且口服方便,安全可靠、无明显毒副作用,患者满意,接受程度高。
[Abstract]:Objective: to observe the changes of body mass index (BMI), liver function, blood lipid, symptoms and abdominal B-ultrasound in patients with non-alcoholic steatohepatitis (NASH) with phlegm-stasis syndrome treated with Qutan Huoxue granule before and after treatment. To evaluate the clinical efficacy of Qutan Huoxue granule in the treatment of phlegm-stasis syndrome in patients with non-alcoholic steatohepatitis. Methods: 66 NASH patients with phlegm-stasis syndrome were randomly divided into treatment group and control group. The treatment group was treated with Qutan Huoxue granule and the control group was treated with polyene phosphatidylcholine capsules. After 3 months treatment, the body mass index (BMI), symptoms, liver function (ALT,AST,GGT), blood lipid (TG,TC,HDL-C) and abdominal ultrasound were compared between the two groups before and after treatment. Results: (1) there was no difference in baseline data between the two groups. The safety indexes were not abnormal (P0.05). (2). There were significant differences in body mass index, TCM symptom score, liver function and blood lipid between the two groups after treatment and before treatment (P0.05), and there were significant differences between the two groups (P0.05). It has good therapeutic effect. There was no significant difference between the two groups after treatment (P0.05). (- 3). There was no significant difference between the two groups before and after B-ultrasound treatment (P0.05), and there was no significant difference between the two groups after treatment (P0.05). Conclusion: (1) Qutan Huoxue granule can reduce body mass index (BMI), improve clinical symptoms, improve liver function and blood lipid, especially for symptoms (hypochondriac pain, flank distension), especially for symptoms (hypochondriac pain, flank distension). (2) Qutan Huoxue granule is superior to polyene phosphatidylcholine capsule group in the treatment of phlegm-stasis syndrome NASH. (3) Qutan Huoxue granule in treatment of phlegm-stasis syndrome NASH on abdominal B-ultrasound imaging. The change has little effect. (4) the decoction of dispelling phlegm and promoting blood circulation is used in differentiation of symptoms and signs of traditional Chinese medicine. Compatibility is reasonable, not only effective, but also easy to take, safe and reliable, no obvious toxic and side effects, patients satisfied, high acceptance.
【学位授予单位】：西南医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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