补肾健脾汤治疗早中期慢性肾衰脾肾阳虚证的临床疗效观察

发布时间：2019-04-26 01:23

【摘要】：目的:观察补肾健脾汤治疗早中期慢性肾功能衰竭脾肾阳虚证的临床疗效,从而为临床对早中期慢性肾衰脾肾阳虚证的治疗提供更为有效的方法。方法:选取60例临床慢性肾衰脾肾阳虚证患者(符合排除标准及纳入标准),将其分随机为治疗组、对照组各30例,给予两组病人西医基础治疗的同时,分别给予治疗组补肾健脾汤加减(日一剂,水煎2次取汁约200ml,于早晚各温服100ml)治疗及对照组以尿毒清颗粒(1包/次,冲服,4次/日)治疗,均持续治疗1个月后在治疗前后比较两组的中医证候改善及血肌酐(Scr)、内生肌酐清除率(Ccr)、血尿素氮(BUN)、血红蛋白(Hb)、白蛋白(ALB)、尿蛋白的变化并比较二组的中医症候疗效和临床疾病综合疗效。结果:两组患者年龄、病程、性别及肾功能分期分布上无显著差异(P0.05)。治疗后两组患者中医症候、Scr、Ccr、BUN、Hb、ALB较治疗前均有明显好转(P0.05)。尿蛋白于对照组治疗前后无显著改变(P0.05),仅在治疗组治疗后显著下降(P0.05)。治疗组中医症候、Scr、Ccr、BUN、尿蛋白、Hb及ALB于治疗前后改善幅度显著大于对照组(P0.05)。治疗后中医证候总积分两组均显著低于治疗前(P0.05),且治疗后中医证候总积分治疗组明显低于对照组(P0.05)。中医证候疗效和疾病临床综合疗效治疗组均显著优于对照组(P0.05)。结论:补肾健脾汤对早中期慢性肾衰脾肾阳虚型患者的中医证候疗效和疾病临床综合疗效均优于尿毒清颗粒,可进一步临床推广。
[Abstract]:Objective: to observe the clinical effect of Bushen Jianpi decoction on spleen-kidney yang deficiency syndrome in early and middle stage of chronic renal failure, so as to provide a more effective method for the treatment of spleen-kidney yang deficiency syndrome in early and middle stage of chronic renal failure. Methods: 60 patients with chronic renal failure with deficiency of spleen and kidney yang were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). The patients in the treatment group were treated with Bushen Jianpi decoction (one dose per day, decoction of water twice, about 200ml) and the control group were treated with Niaoduqing granule (1 pack per day, 4 times a day), while the patients in the control group were treated with 100ml at every temperature in the morning and evening, and the patients in the control group were treated with Niaoduqing granule. The improvement of TCM syndrome and creatinine (Scr), endogenous creatinine clearance rate (Ccr), blood urea nitrogen (BUN), hemoglobin (Hb), albumin (ALB), before and after treatment were compared between the two groups before and after treatment for 1 month. The changes of urinary protein were compared between the two groups. Results: there was no significant difference in age, course of disease, sex and renal function stage distribution between the two groups (P0.05). After treatment, two groups of patients with TCM symptoms, Scr,Ccr,BUN,Hb,ALB was significantly better than before treatment (P0.05). There was no significant change in urine protein before and after treatment in the control group (P0.05), only significantly decreased after treatment in the treatment group (P0.05). The improvement of Scr,Ccr,BUN, urine protein, Hb and ALB before and after treatment in the treatment group was significantly higher than that in the control group (P0.05). After treatment, the total score of TCM syndrome in the two groups was significantly lower than that before treatment (P0.05), and the total score of TCM syndrome in the treatment group after treatment was significantly lower than that in the control group (P0.05). The therapeutic effect of TCM syndrome and the clinical comprehensive curative effect of disease in the treatment group were significantly better than those in the control group (P0.05). Conclusion: Bushen Jianpi decoction is superior to Naoduqing granule in the treatment of early and middle stage chronic renal failure patients with deficiency of spleen and kidney yang in TCM syndrome and clinical comprehensive curative effect. It can be further extended in clinical practice.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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