早搏灵胶囊对室性期前收缩患者QTd及HRV影响的研究
发布时间：2019-05-05 21:09
【摘要】：目的：通过观察频发室性期前收缩患者应用早搏灵胶囊后对QT离散度及心率变异性的影响,来评估复方中药治疗本病的的疗效和安全性。方法：本研究为自身对照研究,选取80例频发室性期前收缩的患者,男35例,女45例,平均年龄在59.61±12..34岁。所有患者均来自黑龙江中医药大学附属第一医院心内二科门诊。主要终点是观察患者应用早搏灵胶囊治疗前及治疗后的QT离散度(QT dispersion,QTd)、校正QT离散度(Heartrate-corrected QT dispersion,QTcd)和心率变异性(Heart rate variabil ity,HRV)的变化,次要终点是观察治疗后室早数量变化及早搏灵胶囊的疗效和安全性。所有患者均口服早搏灵胶囊4粒／次,3次／日。观察患者服药前及服药4周后动态心电图QTd、QTcd及HRV变化。数据采用SPSS22.0软件分析结果。结果：(1)早搏灵胶囊能明显降低室早数量(P0.05),24h平均心率在治疗后无差异(P0.05)。(2)QT、QTc治疗前后无明显统计学意义(P0.05)、QTd及QTcd与治疗前相比,差异有统计学意义(P0.01)。(3)治疗前后的QT max和QTc max差异有统计学意义(P0.05)。QT min和QTc min治疗前后差异无统计学意义(P0.05)。(4)HRV时域指标SDNN、SDANN、 SDNNindex、 pNN50、RMSSD及频域指标LF、HF,与治疗前相比,差异有统计学意义(P0.01)。LF/HF比值,用药前后无差异(P0.05)。结论：1.早搏灵胶囊能缩短室早患者的0Td及QTcd。2.早搏灵胶囊能改善心脏自主神经功能,提高心率变异性。
[Abstract]:Aim: to evaluate the efficacy and safety of compound Chinese medicine on QT dispersion and heart rate variability (HRV) in patients with frequent ventricular extrasystole by observing the effect of Zoboling capsule on VPV dispersion and heart rate variability (HRV) in patients with frequent ventricular extrasystole. Methods: 80 patients (35 males and 45 females) with frequent ventricular extrasystole were selected as a self-control study. The mean age was 59.61 卤12.34 years old. All patients from the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine Heart 2 out-patient. The main endpoint was to observe the changes of QT dispersion (QT dispersion,QTd), corrected QT dispersion (Heartrate-corrected QT dispersion,QTcd) and heart rate variability (Heartrate variabil ity,HRV) before and after treatment with Zoboling capsule. The secondary end point is to observe the changes of ventricular premature quantity after treatment and the efficacy and safety of Bering capsule. All patients took Zoboling capsule 4 times, 3 times a day. The changes of QTd,QTcd and HRV were observed before and 4 weeks after treatment. The data were analyzed by SPSS22.0 software. Results: (1) Zaobaoling capsule could significantly reduce the number of ventricular premature (P0.05), and the 24-hour mean heart rate had no significant difference after treatment (P0.05). (2). There was no significant difference before and after QT,QTc treatment (P0.05). Compared with pre-treatment, QTd and QTcd, There was significant difference in QT max and QTc max before and after treatment (P0.01). (3). There was no significant difference between). QT min and QTc min before and after treatment (P0.05). (4) HRV time domain index SDNN,SDANN, (P0.05). (4). There was significant difference in SDNNindex, pNN50,RMSSD and frequency domain index LF,HF, between before and after treatment (P0.01). LF / HF ratio had no difference before and after treatment (P0.05). Conclusion: 1. 0Td and QTcd.2. of Zaoerling capsule in patients with short Ventricular premature Zaobaoling capsule can improve the function of cardiac autonomic nerve and increase heart rate variability.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2469911
[Abstract]:Aim: to evaluate the efficacy and safety of compound Chinese medicine on QT dispersion and heart rate variability (HRV) in patients with frequent ventricular extrasystole by observing the effect of Zoboling capsule on VPV dispersion and heart rate variability (HRV) in patients with frequent ventricular extrasystole. Methods: 80 patients (35 males and 45 females) with frequent ventricular extrasystole were selected as a self-control study. The mean age was 59.61 卤12.34 years old. All patients from the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine Heart 2 out-patient. The main endpoint was to observe the changes of QT dispersion (QT dispersion,QTd), corrected QT dispersion (Heartrate-corrected QT dispersion,QTcd) and heart rate variability (Heartrate variabil ity,HRV) before and after treatment with Zoboling capsule. The secondary end point is to observe the changes of ventricular premature quantity after treatment and the efficacy and safety of Bering capsule. All patients took Zoboling capsule 4 times, 3 times a day. The changes of QTd,QTcd and HRV were observed before and 4 weeks after treatment. The data were analyzed by SPSS22.0 software. Results: (1) Zaobaoling capsule could significantly reduce the number of ventricular premature (P0.05), and the 24-hour mean heart rate had no significant difference after treatment (P0.05). (2). There was no significant difference before and after QT,QTc treatment (P0.05). Compared with pre-treatment, QTd and QTcd, There was significant difference in QT max and QTc max before and after treatment (P0.01). (3). There was no significant difference between). QT min and QTc min before and after treatment (P0.05). (4) HRV time domain index SDNN,SDANN, (P0.05). (4). There was significant difference in SDNNindex, pNN50,RMSSD and frequency domain index LF,HF, between before and after treatment (P0.01). LF / HF ratio had no difference before and after treatment (P0.05). Conclusion: 1. 0Td and QTcd.2. of Zaoerling capsule in patients with short Ventricular premature Zaobaoling capsule can improve the function of cardiac autonomic nerve and increase heart rate variability.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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