加味清心莲子饮治疗中老年再发性尿路感染的临床疗效观察

发布时间：2019-05-10 18:26

【摘要】：目的:通过临床研究观察加味清心莲子饮治疗中老年再发性尿路感染的临床疗效,并探讨其作用机制,为临床中西医结合治疗中老年人再发性尿路感染提供新方案和新思路。方法:将符合入选标准的自2014年4月至2015年12月在山东中医药大学附属医院及山东省立医院肾内科住院的患者60例,随机分为2组,试验组和对照组各30例。对照组给予西药抗生素分期减量治疗方法,试验组在对照组的基础上予加味清心莲子饮。疗程12个周,随访6周。分别观察治疗前后中医证候总积分、尿白细胞、尿红细胞及尿培养的变化。结果:共有59例患者完成12周临床观察。(1)临床总有效率:试验组临床治愈17人(56.67%)、有效9人(30%)、无效4人(13.33%),总有效率为86.67%;对照组临床治愈11人(37.93%)、有效7人(24.14%)、无效11人(37.93%),总有效率为62.07%。两组比较,试验组疗效明显优于对照组(P0.05)。(2)尿常规变化:治疗后尿白细胞、红细胞检查较治疗前显著下降,试验组较对对照组下降更为明显(P0.05)。(3)中医证候疗效:试验组临床治愈18人(60%)、显效5人(16.67%)、有效2人(6.67%),无效5人(16.67%),总有效率为83.34%;对照组临床治愈6人(20.69%)、显效5人(17.24%)、有效2人(6.90%)、无效16人(55.17%),总有效率为44.83%。两组比较,试验组疗效优于对照组(P0.05)。结论:加味清心莲子饮联合应用抗生素治疗中老年再发性尿路感染对减轻患者的临床症状、降低复发率具有明显的作用。
[Abstract]:Objective: to observe the clinical effect of Jiawei Qingxin Lianzi decoction in the treatment of recurrent urinary tract infection in the middle and old age, and to explore its mechanism, so as to provide a new scheme and new idea for the clinical treatment of recurrent urinary tract infection in the middle aged and the elderly. Methods: from April 2014 to December 2015, 60 patients hospitalized in the affiliated Hospital of Shandong University of traditional Chinese Medicine and Shandong Provincial Hospital were randomly divided into two groups: experimental group (n = 30) and control group (n = 30). The control group was treated with western medicine antibiotics by stages, and the experimental group was given Jiawei Qingxinlian seed drink on the basis of the control group. The course of treatment was 12 weeks and followed up for 6 weeks. The changes of total score of TCM syndromes, urine white blood cells, urine red blood cells and urine culture were observed before and after treatment. Results: a total of 59 patients completed 12-week clinical observation. (1) Clinical total effective rate: 17 patients (56.67%) were cured, 9 patients (30%) were effective, 4 patients (13.33%) were ineffective, and the total effective rate was 86.67%. In the control group, 11 cases (37.93%) were cured, 7 cases (24.14%) were effective, 11 cases (37.93%) were ineffective, and the total effective rate was 62.07%. Compared with the two groups, the curative effect of the experimental group was significantly better than that of the control group (P 0.05). (2). The changes of urine leukocytes and red blood cells after treatment were significantly lower than those before treatment. The therapeutic effect of TCM syndrome in the test group was more obvious than that in the control group (P0.05). (3): 18 cases (60%), 5 cases (16.67%), 2 (6.67%), 5 (16.67%), 5 (16.67%) were cured, 5 (16.67%), 5 (16.67%), respectively. The total effective rate was 83. 34%. In the control group, 6 cases (20.69%) were cured, 5 cases (17.24%) were markedly effective, 2 cases (6.90%) were effective, 16 cases (55.17%) were ineffective, and the total effective rate was 44.83%. Compared with the two groups, the therapeutic effect of the experimental group was better than the control group (P0.05). Conclusion: Jiawei Qingxin Lianzi decoction combined with antibiotics in the treatment of recurrent urinary tract infection in middle-aged and elderly patients has obvious effect on alleviating the clinical symptoms and reducing the recurrence rate.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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