参桂护心汤化裁治疗HFpEF（心阳不振型）的临床疗效观察
发布时间：2019-05-20 02:13
【摘要】：目的:观察参桂护心汤化裁治疗射血分数保留心力衰竭(HFpEF)(心阳不振型)患者的临床疗效,为中医临床治疗提供一定的思路。方法:入选患者为2016年1月～2016年12月期间在黑龙江中医药大学附属第一医院心内科门诊就诊的心阳不振型射血分数保留心力衰竭患者64例,运用随机方法分入治疗组以及对照组,每组32例。对照组应用常规西药治疗,治疗组则在对照组治疗基础上联合参桂护心汤化裁进行治疗,疗程为8周。其中治疗组30例完成研究观察,对照组29例完成研究观察。比较治疗前后心功能分级、中医证候积分、血BNP、Hcy水平以及超声心动图指标(e',E/e',LVMI)。结果:(1)心功能分级疗效:对照组总体有效率为65.52%,治疗组总体有效率为86.67%;2组间进行比较,具有显著统计学差异(P0.05),治疗组改善心功能分级的疗效优于对照组。(2)中医证候积分:经治疗后2组积分均下降(P0.01),治疗组比对照组降低积分更明显,具有显著统计学差异(P0.05)。对照组总有效率为65.52%,治疗组总有效率为90.00%;组间比较具有极显著统计学差异(P0.01),治疗组改善中医证候的效果更优。(3)Hcy及BNP水平:经治疗后2组Hcy及BNP水平均较前下降(P0.01),组间比较,治疗组降低Hcy及BNP水平的效果更优,具有极显著统计学差异(P0.01)。(4)超声心动图指标:2组治疗前后e',E/e',LVMI进行比较,指标均有改善(P0.01),对治疗后e'及E/e'进行组间比较,具有显著统计学差异(P0.05),对治疗后LVMI进行组间比较,无统计学差异(P0.05),总体来说,治疗组改善心脏舒张功能的效果更佳。结论:(1)参桂护心汤化裁可改善HFpEF(心阳不振型)患者的心衰临床症状及中医证候。(2)参桂护心汤化裁可降低HFpEF(心阳不振型)患者的Hcy及BNP水平。(3)参桂护心汤化裁可改善HFpEF(心阳不振型)患者的心脏舒张功能。
[Abstract]:Objective: to observe the clinical effect of Shengui Huaxin decoction in the treatment of (HFpEF) (patients with heart failure with ejection fraction retention (EF), and to provide some ideas for the clinical treatment of traditional Chinese medicine (TCM). Methods: from January 2016 to December 2016, 64 patients with heart failure were enrolled in the outpatient Department of Cardiology, the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. The patients in each group were randomly divided into treatment group (n = 32) and control group (n = 32). The control group was treated with conventional western medicine, while the treatment group was treated with Shengui Huaxin decoction on the basis of the control group. The course of treatment was 8 weeks. Among them, 30 cases in the treatment group and 29 cases in the control group completed the study observation. The cardiac function grade, TCM syndrome score, blood BNP,Hcy level and echocardiography indexes were compared before and after treatment. Results: (1) the overall effective rate was 65.52% in the control group and 86.67% in the treatment group. There was significant difference between the two groups (P 0.05). The curative effect of the treatment group on improving cardiac function grade was better than that of the control group. (2) TCM syndrome score: after treatment, the scores of the two groups decreased (P 0.01). Compared with the control group, the treatment group decreased the score more significantly, with significant difference (P 0.05). The total effective rate was 65.52% in the control group and 90.00% in the treatment group. There was significant difference between the two groups (P 0.01), and the effect of the treatment group on improving TCM syndromes was better. (3) the levels of Hcy and BNP: after treatment, the levels of Hcy and BNP in the two groups were lower than those before treatment (P 0.01), and the levels of Hcy and BNP in the treatment group were lower than those before treatment. The effect of reducing Hcy and BNP levels in the treatment group was better than that in the treatment group, and there was significant difference between the two groups (P 0.01). (4). Before and after treatment, the indexes of E, E and LVMI in the two groups were improved (P 0.01), and there was a significant difference between the two groups before and after treatment (P 0.01). There was significant difference between the two groups after treatment (P 0.05). There was no significant difference in LVMI between the two groups after treatment (P 0.05). In general, there was no significant difference between the two groups (P 0.05), and there was no significant difference between the two groups after treatment (P 0.05). The effect of treatment group on improving cardiac diastolic function was better. Conclusion: (1) Shengui Huaxin decoction can improve the clinical symptoms and TCM syndromes of HFpEF patients with heart failure. (2) Shengui Huxin decoction can reduce the levels of Hcy and BNP in HFpEF patients. (2) Shengui Huxin decoction can reduce the levels of Hcy and BNP in patients with Xinyang. ( 3) Shengui Huxin decoction can improve the diastolic function of HFpEF patients.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
本文编号：2481265
[Abstract]:Objective: to observe the clinical effect of Shengui Huaxin decoction in the treatment of (HFpEF) (patients with heart failure with ejection fraction retention (EF), and to provide some ideas for the clinical treatment of traditional Chinese medicine (TCM). Methods: from January 2016 to December 2016, 64 patients with heart failure were enrolled in the outpatient Department of Cardiology, the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. The patients in each group were randomly divided into treatment group (n = 32) and control group (n = 32). The control group was treated with conventional western medicine, while the treatment group was treated with Shengui Huaxin decoction on the basis of the control group. The course of treatment was 8 weeks. Among them, 30 cases in the treatment group and 29 cases in the control group completed the study observation. The cardiac function grade, TCM syndrome score, blood BNP,Hcy level and echocardiography indexes were compared before and after treatment. Results: (1) the overall effective rate was 65.52% in the control group and 86.67% in the treatment group. There was significant difference between the two groups (P 0.05). The curative effect of the treatment group on improving cardiac function grade was better than that of the control group. (2) TCM syndrome score: after treatment, the scores of the two groups decreased (P 0.01). Compared with the control group, the treatment group decreased the score more significantly, with significant difference (P 0.05). The total effective rate was 65.52% in the control group and 90.00% in the treatment group. There was significant difference between the two groups (P 0.01), and the effect of the treatment group on improving TCM syndromes was better. (3) the levels of Hcy and BNP: after treatment, the levels of Hcy and BNP in the two groups were lower than those before treatment (P 0.01), and the levels of Hcy and BNP in the treatment group were lower than those before treatment. The effect of reducing Hcy and BNP levels in the treatment group was better than that in the treatment group, and there was significant difference between the two groups (P 0.01). (4). Before and after treatment, the indexes of E, E and LVMI in the two groups were improved (P 0.01), and there was a significant difference between the two groups before and after treatment (P 0.01). There was significant difference between the two groups after treatment (P 0.05). There was no significant difference in LVMI between the two groups after treatment (P 0.05). In general, there was no significant difference between the two groups (P 0.05), and there was no significant difference between the two groups after treatment (P 0.05). The effect of treatment group on improving cardiac diastolic function was better. Conclusion: (1) Shengui Huaxin decoction can improve the clinical symptoms and TCM syndromes of HFpEF patients with heart failure. (2) Shengui Huxin decoction can reduce the levels of Hcy and BNP in HFpEF patients. (2) Shengui Huxin decoction can reduce the levels of Hcy and BNP in patients with Xinyang. ( 3) Shengui Huxin decoction can improve the diastolic function of HFpEF patients.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
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