复方丹红注射液对血管性认知障碍患者的认知行为学的临床研究
发布时间：2019-05-30 06:18
【摘要】：目的:观察复方丹红注射液对改善血管性认知障碍患者认知功能损害的临床疗效。方法:本研究从2015年1月至2015年12月我院的住院及门诊病人中选择符合病例纳入标准的血管性认知障碍患者60例,并运用计算机随机发生器,随机分为中药治疗组(30例)和西药对照组(30例)。采用随机、对照、单盲的试验方法,治疗组予静滴复方丹红注射液,对照组予口服盐酸多奈哌齐,两组患者的基础治疗为抗血小板聚集、稳定斑块及对症治疗等,观察两组患者治疗前后的ADAS-Cog、MMSE、Mo CA、NIHSS、ADL评分变化及中医证候积分的变化。结果:(1)认知功能:与治疗前相比,治疗组和对照组治疗后的ADAS-Cog分值有所下降,MMSE及Mo CA分值有所增加,差异均有统计学意义(P㩳0.01),但将两组治疗后的评分进行比较,发现无统计学意义(P㧐0.05);对治疗组治疗前后ADAS-Cog、MMSE及Mo CA各子项目分值进一步比较,发现治疗组ADAS-Cog子项目中的单词回忆、命名、指令、单词辨认、回忆测验指令、找词困难、语言理解能力、注意力等方面分值下降明显(P0.01),在意向性练习方面分值有所下降(P0.05),而在结构性练习、定向力、口语能力方面分值下降不明显(P0.05);治疗组MMSE各子项目中在记忆力、注意力和计算力、回忆力等方面改善明显,差异有显著统计学意义(P0.01),而在定向力、语言能力方面改善不明显,差异无统计学意义(P0.05);治疗组Mo CA各子项目中在注意力、延迟回忆方面改善明显,差异具有显著统计学意义(P0.01),在命名能力方面有一定改善(P0.05),而在视空间与执行能力、语言能力、抽象力、定向力方面改善不明显(P0.05)。(2)神经功能缺损与日常生活能力:治疗组治疗后与治疗前相比,NIHSS及ADL的评分均下降明显,差异有显著统计学意义(P㩳0.01),而对照组治疗后与治疗前相比,NIHSS评分下降不明显(P㧐0.05),ADL评分有所下降(P㩳0.01)。(3)中医证候:与治疗前相比,治疗组治疗后的中医证候积分下降明显(P㩳0.01),对照组治疗后的中医证候积分与治疗前相比差异无统计学意义(P㧐0.05)。结论:(1)复方丹红注射液和盐酸多奈哌齐均能改善血管性认知障碍患者的认知,延缓其病程,并且复方丹红注射液对认知的改善主要集中在记忆力、注意力、回忆力等方面。(2)复方丹红注射液在改善血管性认知障碍患者的神经功能缺损方面优于盐酸多奈哌齐,但在改善日常生活能力方面疗效相当;(3)复方丹红注射液在改善血管性认知障碍患者的中医证候方面优于盐酸多奈哌齐。(4)复方丹红注射液临床使用疗效满意,且安全性高,无不良反应。
[Abstract]:Objective: to observe the clinical effect of compound Danhong injection on improving cognitive impairment in patients with vascular cognitive impairment. Methods: from January 2015 to December 2015, 60 patients with vascular cognitive impairment were selected from inpatients and outpatients in our hospital, and computer random generators were used. They were randomly divided into traditional Chinese medicine treatment group (n = 30) and western medicine control group (n = 30). The treatment group was treated with compound Danhong injection intravenously, and the control group was treated with oral Donepazide hydrochloric acid. The basic treatments of the two groups were antiplatelet aggregation, stable plaque and symptomatic treatment. The changes of ADAS-Cog,MMSE,Mo CA,NIHSS,ADL score and TCM syndrome score before and after treatment were observed. Results: (1) Cognitive function: compared with before treatment, the ADAS-Cog score of the treatment group and the control group decreased, MMSE and Mo CA scores increased, the difference was statistically significant (P 鈮，
本文编号：2488597
[Abstract]:Objective: to observe the clinical effect of compound Danhong injection on improving cognitive impairment in patients with vascular cognitive impairment. Methods: from January 2015 to December 2015, 60 patients with vascular cognitive impairment were selected from inpatients and outpatients in our hospital, and computer random generators were used. They were randomly divided into traditional Chinese medicine treatment group (n = 30) and western medicine control group (n = 30). The treatment group was treated with compound Danhong injection intravenously, and the control group was treated with oral Donepazide hydrochloric acid. The basic treatments of the two groups were antiplatelet aggregation, stable plaque and symptomatic treatment. The changes of ADAS-Cog,MMSE,Mo CA,NIHSS,ADL score and TCM syndrome score before and after treatment were observed. Results: (1) Cognitive function: compared with before treatment, the ADAS-Cog score of the treatment group and the control group decreased, MMSE and Mo CA scores increased, the difference was statistically significant (P 鈮，
本文编号：2488597
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