补肾益精法治疗肾精不足型高血压病的临床研究
发布时间：2019-06-13 09:16
【摘要】：目的:观察探究左归丸对肾精不足型高血压病的药理作用,临床疗效和作用机制,评价其临床运用的安全性。为临床治疗高血压提供有价值的新的治疗方法。方法:按照纳入和排除标准,选山东中医药大学第一附属医院综合内科住院病例共60例,随机分为试验组和对照组各30例。两组患者治疗前一般情况用spss软件统计,无明显统计学差异。对照组用西药氯沙坦治疗,试验组在用氯沙坦基础上加中药汤剂左归丸,一日一剂,分两次温服。4周后进行临床疗效评定。并于治疗前、后行一般项目检查:脉搏、呼吸、心率、肝功、肾功、心电图等检查,观察两组患者治疗前后的诊室血压,动态血压、肝功、肾功、症状严重程度、中医症状总积分、中医总疗效、单项症状疗效判定等,从而评价左归丸的疗效及安全性。结果:经研究发现,左归丸可以明显降低患者血压水平,对比两组临床疗效,治疗组对照组无显著降压差异;中医症状上,试验组优于对照组(P0.05);中医单项症状方面,试验组优于对照组(P0.05);中医症状总积分方面,试验组优于对照组(P0.05);总疗效方面,试验组明显优于对照组(P0.05)。胆固醇等血脂比较,实验组优于对照组(P0.05)。在肝肾功能安全性指标方面治疗前后无明显变化(P0.05),提示左归丸应用安全。结论:左归丸具降压效果良好,并能缓解患者的临床症状,临床作用较安全。
[Abstract]:Objective: to observe the pharmacological effect, clinical efficacy and mechanism of Zuogui Pill on hypertension of kidney essence deficiency type, and to evaluate the safety of its clinical application. It provides a valuable new treatment for clinical treatment of hypertension. Methods: according to the criteria of inclusion and exclusion, 60 inpatients in the Department of General Medicine, the first affiliated Hospital of Shandong University of traditional Chinese Medicine were randomly divided into experimental group (n = 30) and control group (n = 30). Before treatment, the general situation of the two groups was counted by spss software, and there was no significant difference between the two groups. The control group was treated with western medicine losartan, and the experimental group was treated with Zuogui pills, one dose a day, on the basis of losartan. The clinical efficacy was evaluated 4 weeks later. Before and after treatment, general items were examined: pulse, respiration, heart rate, liver function, kidney function, electrocardiogram and so on. The clinical blood pressure, ambulatory blood pressure, liver function, kidney function, symptom severity, total score of traditional Chinese medicine symptoms, total curative effect of traditional Chinese medicine, single symptom curative effect and so on were observed before and after treatment, so as to evaluate the efficacy and safety of Zuogui pills. Results: it was found that Zuogui Pill could significantly reduce the blood pressure level of the patients. Compared with the clinical efficacy of the two groups, the treatment group had no significant difference in reducing blood pressure; in the TCM symptoms, the experimental group was superior to the control group (P 0.05); in the single symptom of traditional Chinese medicine, the experimental group was superior to the control group (P 0.05); in the total score of TCM symptoms, the experimental group was superior to the control group (P 0.05). In terms of total curative effect, the experimental group was significantly better than the control group (P 0.05). Compared with cholesterol and other blood lipids, the experimental group was better than the control group (P 0.05). There was no significant change in the safety index of liver and kidney function before and after treatment (P 0.05), suggesting that Zuogui pills is safe to use. Conclusion: Zuogui Pill has good antihypertensive effect and can relieve the clinical symptoms of the patients, and the clinical effect is safe.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2498423
[Abstract]:Objective: to observe the pharmacological effect, clinical efficacy and mechanism of Zuogui Pill on hypertension of kidney essence deficiency type, and to evaluate the safety of its clinical application. It provides a valuable new treatment for clinical treatment of hypertension. Methods: according to the criteria of inclusion and exclusion, 60 inpatients in the Department of General Medicine, the first affiliated Hospital of Shandong University of traditional Chinese Medicine were randomly divided into experimental group (n = 30) and control group (n = 30). Before treatment, the general situation of the two groups was counted by spss software, and there was no significant difference between the two groups. The control group was treated with western medicine losartan, and the experimental group was treated with Zuogui pills, one dose a day, on the basis of losartan. The clinical efficacy was evaluated 4 weeks later. Before and after treatment, general items were examined: pulse, respiration, heart rate, liver function, kidney function, electrocardiogram and so on. The clinical blood pressure, ambulatory blood pressure, liver function, kidney function, symptom severity, total score of traditional Chinese medicine symptoms, total curative effect of traditional Chinese medicine, single symptom curative effect and so on were observed before and after treatment, so as to evaluate the efficacy and safety of Zuogui pills. Results: it was found that Zuogui Pill could significantly reduce the blood pressure level of the patients. Compared with the clinical efficacy of the two groups, the treatment group had no significant difference in reducing blood pressure; in the TCM symptoms, the experimental group was superior to the control group (P 0.05); in the single symptom of traditional Chinese medicine, the experimental group was superior to the control group (P 0.05); in the total score of TCM symptoms, the experimental group was superior to the control group (P 0.05). In terms of total curative effect, the experimental group was significantly better than the control group (P 0.05). Compared with cholesterol and other blood lipids, the experimental group was better than the control group (P 0.05). There was no significant change in the safety index of liver and kidney function before and after treatment (P 0.05), suggesting that Zuogui pills is safe to use. Conclusion: Zuogui Pill has good antihypertensive effect and can relieve the clinical symptoms of the patients, and the clinical effect is safe.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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