滋阴补阳方序贯疗法对排卵障碍性不孕症IUI周期的临床观察

发布时间：2019-06-18 23:56

【摘要】：目的:研究滋阴补阳方序贯疗法对排卵障碍性不孕证IUI促排卵周期的临床疗效的观察。研究滋阴补阳方序贯疗法的作用机制,为中西医结合治疗排卵障碍性不孕症提供依据。方法:回顾性分析2012年1月-2015年2月在江苏省中医院生殖医学科因排卵障碍不孕症行夫精人工授精的197个周期。根据其治疗方案分为两组。对照组(克罗米芬组)94个周期,观察组(克罗米芬+滋阴补阳方序贯疗法)103个周期。观察两组的Gn总量,Gn天数,HCG日子宫内膜厚度及形态,单卵泡发育情况,妊娠率与妊娠结局。结果:观察组(中西医组)的Gn总量与Gn天数均显著低于对照组(西医组),P0.05。观察组的单卵泡发育的周期数大于对照组,P0.05,疗效有显著差异。观察组的妊娠率高于对照组,疗效有显著差异,p0.05。观察组的治愈率,治愈率与有效率的总和均明显高于对照组,P0.05。对照组HCG日子宫内膜厚度8.73±2.29mm,A型内膜数36,观察组HCG日子宫内膜厚度9.02±2.23mm,A型内膜数39,观察组HCG日子宫内膜厚度与A型内膜数均高于对照组,但P0.05,无显著疗效。观察组的活婴率、单胎率高于对照组,但疗效无明显差异,P0.05。结论:滋阴补阳方序贯疗法联合西药促排卵可减少Gn总量与Gn天数,从而减少对卵巢的刺激,促进单卵泡发育。同时,西药联合滋阴补阳方序贯疗法,可显著提高卵泡质量与妊娠率。
[Abstract]:Objective: to study the clinical effect of sequential therapy of nourishing yin and tonifying yang on IUI induction cycle of ovulatory disorder infertile syndrome. To study the mechanism of sequential therapy of nourishing yin and tonifying yang prescription, and to provide the basis for the treatment of ovulatory sterility with integrated traditional Chinese and western medicine. Methods: from January 2012 to February 2015, 197 cycles of artificial indoctrination due to ovulatory disorder in reproductive medicine department of Jiangsu Provincial Hospital of traditional Chinese Medicine were analyzed retrospectively. the results showed that 197 cycles of artificial indoctrination were performed in Jiangsu Provincial Hospital of traditional Chinese Medicine. According to its treatment plan, it was divided into two groups. The control group (clomiphene group) 94 cycles, the observation group (clomiphene Ziyin Buyang recipe sequential therapy) 103 cycles. The total Gn, Gn days, intimal thickness and morphology, single follicular development, pregnancy rate and pregnancy outcome were observed. Results: the total Gn and Gn days in the observation group were significantly lower than those in the control group (P 0.05). The number of cycles of single follicular development in the observation group was larger than that in the control group, P 0.05, and the curative effect was significantly different. The pregnancy rate in the observation group was higher than that in the control group, and the curative effect was significantly different, p0.05. The cure rate, cure rate and effective rate in the observation group were significantly higher than those in the control group (P 0.05). The intimal thickness of HCG day was 8.73 卤2.29mm, the number of type A intima was 36, the intimal thickness of observation group was 9.02 卤2.23mm, and the number of type A intima was 39. the intimal thickness of HCG day and type A intima in observation group were higher than those in control group, but there was no significant effect of P0.05. The live infant rate and single fetus rate in the observation group were higher than those in the control group, but there was no significant difference in the curative effect. Conclusion: the sequential therapy of Ziyin Buyang recipe combined with western medicine can reduce the total amount of Gn and Gn days, thus reduce the stimulation of ovaries and promote the development of single follicles. At the same time, western medicine combined with Ziyin Buyang recipe sequential therapy can significantly improve follicular quality and pregnancy rate.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.14

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