血瘀证的病理机制研究近况

发布时间：2019-06-21 20:36

【摘要】：从血管内皮功能、基因组学研究、代谢组学研究等3个方面,对近年来运用现代医学方法探讨血瘀证病理机制的研究进行概述。血瘀证与血管内皮细胞功能障碍具有相关性,血管内皮细胞合成、释放多种活性物质,参与血管舒缩、血栓形成等过程的调节。内皮细胞分泌的血管活性因子主要有血栓素A2/前列环素2(TXA2/PGI2)和内皮素(ET)/一氧化氮(NO)等。血瘀证的基因组学研究主要集中于冠心病和高血压患者;蛋白质组学作为中医证候物质基础的较理想的技术手段,已用于冠心病、高脂血症、动脉粥样硬化等患者差异蛋白表达的鉴定。现代分子生物技术、基因芯片等手段的交汇与融合,使血瘀证的实质研究从过去的宏观转向了微观的客观化水平,将为进一步揭示血瘀证的本质、控制血瘀证的发生发展提供依据。
[Abstract]:This paper summarizes the research on the pathological mechanism of blood stasis syndrome by using modern medical methods in recent years from three aspects: vascular endothelial function, genomics research and metabonomics research. There is a correlation between blood stasis syndrome and vascular endothelial cell dysfunction. Vascular endothelial cells synthesize, release a variety of active substances, and are involved in the regulation of vasoconstriction, thrombosis and other processes. The main vasoactive factors secreted by endothelial cells were thromboxane A2 / proprocyclin 2 (TXA2/PGI2) and Endothelin (ET) / nitric oxide (NO). The genomic research of blood stasis syndrome mainly focuses on patients with coronary heart disease and hypertension. Proteome, as an ideal technical method for the material basis of TCM syndromes, has been used to identify the differential protein expression in patients with coronary heart disease, hyperlipidemia, atherosclerosis and so on. With the intersection and fusion of modern molecular biotechnology and gene chip, the substantive research of blood stasis syndrome has changed from macro to micro objective level, which will provide the basis for further revealing the essence of blood stasis syndrome and controlling the occurrence and development of blood stasis syndrome.
【作者单位】：山东中医药大学;
【基金】：山东省自然科学基金资助项目(编号:ZR2013HM053)
【分类号】：R228

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