自拟生血方加减治疗非小细胞肺癌相关性贫血临床疗效观察

发布时间：2019-07-02 18:27

【摘要】：目的:观察自拟生血方加减治疗非小细胞肺癌相关性贫血的临床疗效。方法:应用随机平行对照方法,将80例住院患者,随机分为两组,对照组40例患者采取常规治疗,治疗组40例患者应用自拟生血方100 m L,日3次口服,治疗21 d为1疗程。观察比较两组患者临床疗效、白细胞(WBC)计数、血红蛋白(Hb)浓度、红细胞(RBC)计数、红细胞比容(HCT)、生存质量评分、中医血虚症状积分、T淋巴细胞亚群(CD+3CD+4CD+8)。结果:治疗后治疗组总有效率为85%,对照组为60%,两组差异明显(P0.05);两组患者血红蛋白、红细胞及白细胞计数及红细胞比容与治疗前相比差异显著(P0.05),且治疗后组间比较,差异明显(P0.05);在生理状况评分上,两组积分均有所减少,但治疗4周期后,治疗组积分低于对照组(P0.05);治疗组的中医症状积分下降,与治疗前及对照组相比,差异显著(P0.05);治疗组CD+3,CD+4,CD+4/CD+8均升高,与治疗前相比差异明显(P0.05)。与对照组治疗后结果相比,差异显著(P0.05)。结论:自拟生血方对非小细胞肺癌相关性贫血的治疗效果显著,可以改善患者症状,提升患者生活质量,提高免疫力,具有临床应用价值。
[Abstract]:Objective: to observe the clinical effect of self-made Shengxue recipe in the treatment of anemia associated with non-small cell lung cancer (NSCLC). Methods: 80 inpatients were randomly divided into two groups. 40 patients in the control group were treated with routine treatment, and 40 patients in the treatment group were treated with self-made Shengxue recipe 100ml three times a day for 21 days as a course of treatment. The clinical efficacy, leukocyte (WBC) count, hemoglobin (Hb) concentration, erythrocyte (RBC) count, erythrocyte specific volume (HCT), quality of life score, TCM blood deficiency symptom score and T lymphocytes subgroup (CD 3CD 4CD 8) were observed and compared between the two groups. Results: after treatment, the total effective rate was 85% in the treatment group and 60% in the control group, the difference between the two groups was significant (P 0.05), the hemoglobin, erythrocyte and white blood cell count and the specific volume of red blood cells in the two groups were significantly different from those before treatment (P 0.05), and there was significant difference between the two groups after treatment (P 0.05). In the physiological status score, the scores of the two groups were decreased, but after 4 cycles of treatment, the scores of the treatment group were lower than those of the control group (P 0.05); the scores of TCM symptoms of the treatment group decreased, which were significantly different from those before treatment and the control group (P 0.05). In the treatment group, CD 3, CD 4, CD 4/CD 8 were significantly higher than those before treatment (P 0.05). Compared with the control group, the difference was significant (P 0.05). Conclusion: the self-made Shengxue recipe is effective in the treatment of anemia associated with non-small cell lung cancer (NSCLC). It can improve the symptoms, improve the quality of life and improve the immunity of patients.
【作者单位】：中国医科大学肿瘤医院辽宁省肿瘤医院;
【基金】：辽宁省自然科学基金项目(2014020101)
【分类号】：R259

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