陈氏清肺方治疗类风湿关节炎合并肺间质病变的临床疗效
发布时间：2019-07-04 21:53
【摘要】：目的探讨陈氏清肺方(太子参、麦冬、沙参,等)治疗类风湿关节炎合并肺间质病变(RA-ILD)的临床疗效。方法均使用强的松用药的RA-ILD患者,用区组随机按数字表法分为对照组和观察组(另加陈氏清肺方)。两组疗程均为3个月。治疗前评价疾病活动度(DAS28),检测红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、抗环瓜氨酸肽抗体(CCP抗体)。进行治疗前后高分辨CT(HRCT)检查并评分及观察记录中医证候体征。结果治疗后观察组在咳嗽、咳痰和气短等中医证候积分有明显改善,总有效率达71%,对照组改善的总有效率为23%。治疗后观察组HRCT肺部影像学改善总有效率68%,对照组总有效率13%。结论在治疗RA用药不变的基础上,陈氏清肺方能明显改善RA-ILD患者的咳嗽、咳痰和气短等症状,HRCT影像学证实能明显改善肺间质病变的面积和严重程度。
文内图片：
图片说明：观察组治疗前后HＲCT检查对比
[Abstract]:Objective to investigate the clinical effect of Chen Shi Qingfei recipe (Panax quinquefolium, Ophiopogon japonicus, Panax quinquefolium, etc.) in the treatment of rheumatoid arthritis complicated with pulmonary stroma lesion (RA-ILD). Methods RA-ILD patients who were treated with prednisone were randomly divided into control group and observation group (plus Chen's Qingfei recipe) according to the method of digital table. The course of treatment in both groups was 3 months. The disease activity (DAS28) was evaluated before treatment, and the erythrocyte sedimentation rate (ESR), C) reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (CCP antibody) was detected. High resolution CT (HRCT) was performed before and after treatment, and the symptoms and signs of TCM syndromes were observed and recorded. Results after treatment, the scores of TCM syndromes such as cough, expectoration and shortness of breath were significantly improved in the observation group, and the total effective rate was 71% in the observation group and 23% in the control group. After treatment, the total effective rate of HRCT pulmonary imaging improvement was 68% in the observation group and 13% in the control group. Conclusion Chen's Qingfei recipe can obviously improve the symptoms of cough, expectoration and shortness of breath in RA-ILD patients on the basis of constant treatment of RA. HRCT imaging can significantly improve the area and severity of pulmonary stroma lesions.
【作者单位】： 扬州大学医学院;上海市光华中西医结合医院;上海中医药大学关节病研究所;
【基金】：上海市长宁区卫生和计划生育委员会科研基金(CNKW2013J05)
【分类号】：R259
本文编号：2510262
文内图片：
图片说明：观察组治疗前后HＲCT检查对比
[Abstract]:Objective to investigate the clinical effect of Chen Shi Qingfei recipe (Panax quinquefolium, Ophiopogon japonicus, Panax quinquefolium, etc.) in the treatment of rheumatoid arthritis complicated with pulmonary stroma lesion (RA-ILD). Methods RA-ILD patients who were treated with prednisone were randomly divided into control group and observation group (plus Chen's Qingfei recipe) according to the method of digital table. The course of treatment in both groups was 3 months. The disease activity (DAS28) was evaluated before treatment, and the erythrocyte sedimentation rate (ESR), C) reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (CCP antibody) was detected. High resolution CT (HRCT) was performed before and after treatment, and the symptoms and signs of TCM syndromes were observed and recorded. Results after treatment, the scores of TCM syndromes such as cough, expectoration and shortness of breath were significantly improved in the observation group, and the total effective rate was 71% in the observation group and 23% in the control group. After treatment, the total effective rate of HRCT pulmonary imaging improvement was 68% in the observation group and 13% in the control group. Conclusion Chen's Qingfei recipe can obviously improve the symptoms of cough, expectoration and shortness of breath in RA-ILD patients on the basis of constant treatment of RA. HRCT imaging can significantly improve the area and severity of pulmonary stroma lesions.
【作者单位】： 扬州大学医学院;上海市光华中西医结合医院;上海中医药大学关节病研究所;
【基金】：上海市长宁区卫生和计划生育委员会科研基金(CNKW2013J05)
【分类号】：R259
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1 高维琴;;风湿性肺间质病变的中医认识[J];河南中医;2013年08期
2 钟丽丹;洪鸿彬;;陈湘君教授治疗风湿病肺间质病变经验介绍[J];新中医;2006年10期
3 李松伟;李桓;王济华;;类风湿关节炎肺间质病变病机探析[J];风湿病与关节炎;2013年03期
，本文编号：2510262
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