114例椎动脉型颈椎病患者中医证素分布及其与血浆内皮素、血清超氧化物歧化酶的相关性

发布时间：2019-07-26 19:21

【摘要】：目的探讨椎动脉型颈椎病的中医证素特征及其与血浆内皮素(ET)、血清超氧化物歧化酶(SOD)的相关性。方法按照中医四诊方法采集114例椎动脉型颈椎病患者的四诊资料,同时检测患者的血浆ET、血清SOD水平,懫用中医证素辨证方法,分析椎动脉型颈椎病患者的中医证素分布特征,采用Logistic逐步回归分析法分析中医证素与血浆ET、血清SOD水平的相关性。结果 114例椎动脉型颈椎病患者常见病位证素分布依次为肾脾肝心胃,常见实性证素依次为寒血瘀湿热气滞,常见虚性证素依次为气虚阴虚血虚阳虚阳亢。男性胃、血虚、阳虚、阳亢证素总权值较女性低,湿证素总权值较女性高(P0.05)。老年肝证素总权值明显低于中年、血虚证素总权值高于中年,中年心证素总权值高于青年(P0.05)。回归分析结果显示,ET为肾、血瘀、热证素的危险因素(OR值分别为1.61、2.72、1.38),SOD为胃、湿证素的危险因素(OR值分别为0.51、0.43)。结论肾、脾、肝为椎动脉型颈椎病的主要病位,实性证素主要为寒、血瘀、湿,虚性证素主要为气虚、阴虚、血虚。当患者血浆ET升高时更容易出现肾、血瘀、热的病理变化,当血清SOD降低时更容易出现胃、湿的病理变化。
[Abstract]:Objective to investigate the characteristics of TCM syndromes of cervical spondylosis of vertebral artery type and its correlation with serum SOD (SOD) of plasma (ET),. Methods according to the four diagnosis methods of traditional Chinese medicine, the four diagnosis data of 114 patients with cervical spondylosis of vertebral artery type were collected, and the serum SOD level of ET, was measured at the same time. The distribution characteristics of TCM syndrome elements in patients with cervical spondylosis of vertebral artery type were analyzed by syndrome differentiation method of traditional Chinese medicine. The correlation between TCM syndrome element and plasma ET, serum SOD level was analyzed by Logistic stepwise regression analysis. Results the distribution of syndrome elements in 114 patients with cervical spondylosis of vertebral artery type was kidney, spleen, liver, heart and stomach in turn, cold blood stasis, dampness and heat stagnation in turn, and deficiency syndrome elements in turn were qi deficiency, yin deficiency, blood deficiency and yang hyperactivity. The total weight of male stomach, blood deficiency and yang hyperactivity syndrome was lower than that of female, and the total weight of wet syndrome was higher than that of female (P 0.05). The total weight value of liver syndrome element in the elderly was significantly lower than that in middle age, the total weight value of blood deficiency syndrome element was higher than that in middle age, and the total weight value of heart syndrome element in middle age was higher than that in young people (P 0.05). The results of regression analysis showed that ET was the risk factor of kidney, blood stasis and heat syndrome (OR = 1.61, 2.72, 1.38), SOD, respectively), and the risk factor of dampness syndrome was 0.51 and 0.43, respectively. Conclusion Kidney, spleen and liver are the main pathological sites of cervical spondylosis of vertebral artery type, and the solid syndrome elements are mainly cold, blood stasis, dampness and deficiency syndrome elements are mainly deficiency of qi, deficiency of yin and deficiency of blood. The pathological changes of kidney, blood stasis and heat were more likely when the plasma ET was increased, and the pathological changes of stomach and dampness were more likely when the serum SOD was decreased.
【作者单位】：北京中医药大学;首都医科大学附属北京中医医院;北京中医药大学第三附属医院;
【分类号】：R274.9

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