利多卡因在蛛网膜下腔和静脉注射致死犬体内的死后分布

发布时间：2018-02-09 17:46

本文关键词： 法医毒物分析利多卡因蛛网膜下腔麻醉静脉注射死后分布　出处：《中国法医学杂志》2009年01期 　论文类型：期刊论文

【摘要】：目的比较利多卡因在蛛网膜下腔和静脉注射致死犬体内的死后分布特点。方法犬12只,其中6只经蛛网膜下腔,另6只经股静脉匀速注入利多卡因(5×15mg/kg)致死,迅速解剖动物,取大脑、侧脑室脑脊液、腰段脊髓腔脑脊液、不同脊髓节段(颈髓、胸髓、腰髓、骶髓),心、肺、肝、脾、肾、胆汁、尿、心血、周围血、注射部位肌肉和注射部位20 cm以外肌肉等脏器组织和体液,用气质联用法定性,气相色谱法定量检测其中利多卡因含量。结果蛛网膜下腔注射致死犬体内利多卡因的含量由高到低顺序依次为腰段脊髓腔脑脊液、骶段脊髓、胸段脊髓、侧脑室脑脊液、腰段脊髓、颈段脊髓、肺、肾、注射部位肌肉、心、大脑、脾、心血、肝、周围血、胆汁、注射部位20 cm以外的肌肉、尿;静脉注射致死犬体内利多卡因的含量由高到低顺序依次为肾、心、肺、脾、大脑、肝、周围血、胆汁、心血、颈段脊髓、胸段脑脊液、注射部位肌肉、腰段脊髓、注射部位20 cm以外的肌肉、侧脑室脑脊液、尿、腰段脊髓腔脑脊液、骶段脊髓。结论蛛网膜下腔注射致死犬背侧脊髓液中利多卡因含量最高,静脉注射致死犬肾脏利多卡因含量最高,此分布特征可为利多卡因麻醉意外法医学鉴定中入体途径的判定提供参考。
[Abstract]:Objective to compare the postmortem distribution of lidocaine in subarachnoid and intravenous lethal dogs. Brain, cerebrospinal fluid of lateral ventricle, cerebrospinal fluid of lumbar spinal cord, different segments of spinal cord (cervical spinal cord, thoracic spinal cord, lumbar spinal cord, sacral spinal cord, heart, lung, liver, spleen, kidney, bile, urine, heart blood, peripheral blood), The visceral tissues and body fluids, such as the muscle at the injection site and the muscle 20 cm away from the injection site, were determined by GC-MS. Results the order of lidocaine content in dogs killed by subarachnoid injection was cerebrospinal fluid (CSF) of lumbar spinal cord, sacral spinal cord, thoracic spinal cord and cerebrospinal fluid of lateral ventricle. Lumbar spinal cord, cervical spinal cord, lung, kidney, muscle at injection site, heart, brain, spleen, heart blood, liver, peripheral blood, bile, muscle 20 cm away from injection site, urine; The contents of lidocaine in dogs killed by intravenous injection were followed by kidney, heart, lung, spleen, brain, liver, peripheral blood, bile, heart blood, cervical spinal cord, thoracic cerebrospinal fluid, muscle at injection site and lumbar spinal cord. The muscle, cerebrospinal fluid (CSF), urine, cerebrospinal fluid (CSF) of lumbar spinal cord and sacral spinal cord were injected 20 cm away from the injection site. Conclusion the content of lidocaine in the dorsal spinal cord fluid of dogs caused by subarachnoid injection is the highest. The content of lidocaine in kidney was the highest in dogs killed by intravenous injection, which could provide reference for the identification of entry pathway in forensic identification of lidocaine anesthesia accident.
【作者单位】：山西医科大学法医学院;山西医科大学第二医院;
【基金】：“十一五”国家科技支撑计划项目(2007BAK26B05) 山西省科技攻关项目(051100-1) 山西省自然科学基金资助项目(20031103)
【分类号】：D919

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