脑认知事件相关电位与不同刺激野相关性的初步研究

发布时间：2018-06-04 15:22

本文选题：正常人 + 事件相关电位(ERP)　；参考：《苏州大学》2009年硕士论文

【摘要】： 目的:通过对不同刺激野ERP成分的对比研究,进而探讨不同视野缺损时视觉信息处理的特征和差异,以期为视野功能的客观评定方法提供基础依据。方法:分别对30名(60只眼)正常视功能被试单眼进行不同刺激野刺激诱发脑电反应,根据刺激野的不同,该实验分为三部分:(1)分别记录全视野、左右视野正方形黑白棋盘格刺激的ERP结果;(2)分别记录全视野、上下视野刺激的ERP结果;(3)分别记录全视野、四个象限视野刺激的ERP结果。结果:(1)左/右视野缺损分别引起对侧枕颞区P1振幅较同侧其振幅低。相反,左/右视野缺损分别诱发对侧半球N1、N2波幅较同侧其波幅大。此外,颞区P1、N1潜伏期在同侧视野缺损条件下比对侧视野缺损条件下明显延长。而N2潜伏期和P3成分在左/右视野间表现相似。(2)与上视野缺损相比,下视野缺损引起枕颞部P1和广泛脑区N1潜伏期显著延长;此外,上视野缺损较下视野缺损诱发出较小P1,而N1振幅表现为上下视野间相似;与下视野缺损对比,上视野缺损引起广泛脑区N2和中央顶区P3潜伏期显著延长,以及较小N2,而P3振幅在上下视野间无差异。(3)颞-顶区N1潜伏期在左下象限视野缺损比右上象限视野缺损时延长,而额区和中央区N2潜伏期则与N1相反;枕部N1振幅在左上象限视野缺损比右下象限视野缺损较小,同时顶区N2振幅在上半象限视野缺损比下半象限视野缺损其振幅小。此外,余象限视野缺损ERP成分的潜伏期和振幅大致一样。结论:不同视野ERP结果表明:(1)左/右视野缺损分别引起对侧枕颞区较小的P1和同侧半球较大的N1、N2,但同侧颞区P1、N1潜伏期较对侧其潜伏期明显延长;(2)下视野缺损主要引起ERP早期成分P1和N1潜伏期的延长,而上视野缺损主要引起ERP晚期成分N2和P3潜伏期的延长,以及P1和N2振幅的降低;(3)颞-顶区N1潜伏期在左下象限视野比右上象限视野延长,而额-中央区N2潜伏期与之相反;枕部N1和顶区N2振幅上半象限视野缺损比下半象限视野缺损其振幅低。
[Abstract]:Objective: to explore the characteristics and differences of visual information processing in different visual field defects by comparing the components of ERP in different stimulus fields in order to provide the basis for objective evaluation of visual field function. Methods: the EEG response was induced by different stimulation fields in 30 normal eyes (60 eyes). According to the different stimulus fields, the experiment was divided into three parts: 1) the whole visual field was recorded respectively. The ERP results of left and right visual field stimulation with square black and white checkerboard were as follows: (2) the total visual field and the ERP result of the upper and lower visual field stimulation were recorded respectively; (3) the ERP results of the four quadrant visual field stimulation were recorded respectively. Results (1) the amplitude of P1 in the contralateral occipito-temporal region was lower than that in the ipsilateral region. On the contrary, the amplitude of N _ 1 N _ 2 wave in contralateral hemisphere induced by left / right visual field defect was larger than that in ipsilateral hemisphere. In addition, the latency of P _ (1) N _ (1) N _ (1) in temporal region was significantly longer under ipsilateral visual field defect than in contralateral visual field defect. The N2 latency and P3 components were similar between the left and right visual fields.) compared with the superior visual field defect, the lower visual field defect resulted in a prolonged latency of P1 in the occipito-temporal region and N1 in the extensive brain region. The N _ 1 amplitude of N _ 1 amplitude was similar to that of the upper and lower visual field, and the N _ 2 and P _ 3 latencies of the central parietal region were significantly prolonged by the upper visual field defect compared with the lower visual field defect. The latency of N1 in the temporal-parietal region was longer in the left lower quadrant than in the right upper quadrant, but the N2 latency in the frontal and central regions was opposite to N1. The N 1 amplitude in the occipital region was smaller in the left upper quadrant than in the right lower quadrant, while the N 2 amplitude in the parietal region was smaller in the upper half quadrant than in the lower half quadrant. In addition, the latency and amplitude of ERP components in the residual quadrant visual field defect were approximately the same. Conclusion: the ERP results of different visual fields showed that the left / right visual field defect caused the smaller P1 in the contralateral occipitosporal region and the larger N _ 1N _ 2 in the ipsilateral hemisphere, but the latency of P _ (1) N _ (N1) in the ipsilateral temporal region was significantly longer than that in the contralateral region (P _ (2). The prolongation of the latency of P1 and N1 in the early components of ERP, The upper visual field defect mainly caused the prolongation of the latencies of N2 and P3, and the decrease of the amplitude of P1 and N2) the N1 latency of temporal-parietal region in the left lower quadrant was longer than that in the right upper quadrant, while the N _ 2 latency in the fronto-central region was the opposite. The amplitude of N 1 and N 2 in the occipital region was lower than that in the lower half quadrant.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2009
【分类号】：D919

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