单次摄药毛发分析的研究进展

发布时间：2018-11-23 09:09

【摘要】："迷药犯罪"是指对被害人下药后实施性侵犯、抢劫、诈骗等犯罪行为。单次摄入的镇静催眠类或迷幻类药物在体内迅速代谢,故难以用血液、尿液检测等常规方法来提供摄药证据,而毛发分析的长检测窗特点在解决这类案件时具有重要的价值。单次摄药的毛发分析要求检测方法有很高的灵敏度,需要用二级质谱检测器进行分析,且从头发采样、去污、水解、提取、分析的各环节均应注意防止污染,避免出现假阳性结果。采集的头发必须进行分段分析,除检测对应案发时间的头发段外,还应把其它头发段的检测结果作为对照,据此对分析结果作出严谨、科学的解释。目前已建立了31种镇静催眠药、6种苯丙胺类衍生物、GHB、硫喷妥及其代谢物戊巴比妥以及乙醇代谢物EtG等的检测方法,可以应用于实际案件的毛发分析。
[Abstract]:The "drug crime" refers to the crime of sexual assault, robbery, fraud and so on after the victim is drugged. Single intake of sedative hypnotic or psychedelic drugs is rapidly metabolized in vivo, so it is difficult to provide evidence of drug uptake by routine methods such as blood and urine tests. The characteristics of long window of hair analysis are of great value in solving such cases. The hair analysis of a single drug requires a high sensitivity. It needs to be analyzed by a two-stage mass spectrometry detector, and should be taken care to prevent pollution in all aspects of hair sampling, decontamination, hydrolysis, extraction and analysis. Avoid false positive results. The collected hair must be analyzed in sections. Besides the hair segment corresponding to the time of the crime, the results of other hair segments should also be taken as the control, according to which the analytical results should be strictly and scientifically explained. At present, 31 sedative hypnotics, 6 amphetamines derivatives, GHB, pentobarbital and ethanol metabolite EtG have been established, which can be used in hair analysis in practical cases.
【作者单位】：司法部司法鉴定科学技术研究所上海市法医学重点实验室司法部司法鉴定科学技术研究所上海市法医学重点实验室司法部司法鉴定科学技术研究所上海市法医学重点实验室
【基金】：[科研院所社会公益研究专项编号]GY0601
【分类号】：D919.4

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