血流感染假丝酵母菌菌种构成及其药物敏感性

发布时间：2017-12-31 00:16

本文关键词：血流感染假丝酵母菌菌种构成及其药物敏感性　出处：《中国感染控制杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的分析某院假丝酵母菌血流感染菌种构成及其对抗真菌药物的敏感性,为临床预防和治疗假丝酵母菌血流感染提供依据。方法回顾性分析2009—2013年该院临床科室送检血标本中检出的假丝酵母菌,并对假丝酵母菌血流感染的高危因素进行分析。结果 2009—2013年42例患者血标本分离假丝酵母菌42株,以近平滑假丝酵母菌为主(20株,47.62%),其次为白假丝酵母菌(16株,38.10%)、热带假丝酵母菌(4株,9.52%)、光滑假丝酵母菌(2株,4.76%)。来源科室主要为:急诊监护病房(EICU,11株)、泌尿外科(9株)、心胸外科(8株)等。37例(占88.10%)患者静脉导管与血标本培养出相同的假丝酵母菌,留置静脉导管至血培养阳性和导管培养阳性的平均时间分别为31.47 d和33.18 d;导管和血培养阳性比例随着置管时间的延长均呈上升趋势(均P0.001)。检出的假丝酵母菌对氟康唑、伏立康唑的敏感率均为75.00%~100.00%,对两性霉素B的敏感率均为100.00%;而不同菌种对伊曲康唑的敏感率存在较大差异(0~87.50%)。结论该院假丝酵母菌血流感染菌株以近平滑假丝酵母菌为主,且与静脉导管的使用有关,其对氟康唑、两性霉素B、伏立康唑的敏感性均较高。
[Abstract]:Objective: analysis of Candida bloodstream infection in species composition and their sensitivity to antifungal agents, for clinical prevention and treatment of Candida yeast provides the basis for blood infection. Methods Retrospective analysis of Candida albicans were detected in 2009 - 2013 the hospital clinical departments of inspection of blood samples, and the risk factors of Candida bloodstream infection analysis from 2009 to 2013. Results 42 patients blood samples were isolated 42 strains of Candida, nearly smooth Candida dominated (20 strains, 47.62%), followed by Candida albicans (16 strains, 38.10%), tropical Candida yeast strains (4 strains, 9.52%), Candida glabrata (2 strains. 4.76%). Department for emergency intensive care unit (EICU, 11 strains (9 strains), Department of Urology), cardiothoracic surgery (8 strains),.37 (88.10% cases) of patients with venous catheter and blood samples were cultured Candida same, indwelling venous catheter and blood culture positive The average time of culture positive and catheter were 31.47 D and 33.18 D; and the proportion of positive blood culture catheter with prolonged catheter were increased (P0.001). The detection of Candida albicans to fluconazole, voriconazole susceptibility rate was 75.00%~100.00%, the sensitive rate of amphotericin B was 100% there is a big difference; and different strains of itraconazole susceptibility rate (0~87.50%). Conclusions the Candida bloodstream infection by Candida parapsilosis strains, and the use of intravenous catheter related to fluconazole, amphotericin B and voriconazole were more sensitive.

【作者单位】：广州军区武汉总医院;
【分类号】：R446.5
【正文快照】： azole are all high.[Chin J Infect Control,2016,15(3):172-175]假丝酵母菌常定植在健康人的口腔、皮肤和胃肠道等部位,通常情况下并不致病[1]。但自1979年以来,假丝酵母菌从血液中检出的比例不断增加,已成为血流感染的主要病原菌之一,免疫力受损及患有严重基础疾病的住院患

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