体外转录信使RNA免疫疗法的研究进展

发布时间：2017-12-31 19:08

本文关键词：体外转录信使RNA免疫疗法的研究进展　出处：《细胞与分子免疫学杂志》2016年01期 　论文类型：期刊论文

【摘要】：体外转录信使RNA(IVT mRNA)是在体外条件下以DNA为模板转录得到的一种mRNA,这种mRNA可以指导特定蛋白质的合成,阻止或改变某种特定的疾病。因此,IVT mRNA可以作为一种传递遗传信息的潜在新药。与其他核酸药物相比,基于IVT mRNA的药物具有很多优势。随着mRNA技术发展,基于IVT mRNA的恶性肿瘤免疫疗法和治疗传染性疾病疫苗的研制等已步入临床应用阶段。本文系统地介绍了IVT mRNA的结构、合成方式、投递途径和免疫机制,着重分析了IVT mRNA免疫疗法在不同疾病临床治疗中的应用现状,如恶性肿瘤、传染性疾病和过敏反应等,并探讨了将其开发为新药所遇到的关键性机遇与挑战。
[Abstract]:In vitro transcriptional messenger RNA(IVT (RNA(IVT) is a kind of mRNAs transcribed in vitro using DNA as a template. This kind of mRNA can direct the synthesis of specific proteins. To prevent or alter a particular disease. Therefore, IVT mRNA can be used as a potential new drug to transmit genetic information, compared with other nucleic acid drugs. Drugs based on IVT mRNA have many advantages. With the development of mRNA technology. The immunotherapy of malignant tumor based on IVT mRNA and the development of vaccine for the treatment of infectious diseases have entered the stage of clinical application. This paper systematically introduces the structure and synthesis of IVT mRNA. The delivery pathway and immune mechanism were analyzed, and the application of IVT mRNA immunotherapy in clinical treatment of different diseases, such as malignant tumor, infectious disease and allergic reaction, was analyzed. The key opportunities and challenges for its development as new drugs are also discussed.
【作者单位】：第四军医大学生物医学工程系;第四军医大学学员旅一连;第四军医大学航空航天医学系;
【基金】：国家自然科学基金(81070951;81222015) 第四军医大学博士学位资助课题(2013D01)
【分类号】：R457.2
【正文快照】： 转录通常发生在生物体内,但是在体外无细胞系统中,以DNA为模板,加上RNA聚合酶、核苷酸等条件,模拟体内转录过程也可以合成mRNA。这种体外转录信使RNA(in vitro transcription messenger RNA,IVT mRNA)能够更好地控制转录基因,转录过程与蛋白功能等。IVT mRNA可以将特定的遗传

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