ABCB1基因多态性与中国骨髓移植患者服用环孢素A所致移植后糖尿病的关联分析

发布时间：2017-12-31 21:11

本文关键词：ABCB1基因多态性与中国骨髓移植患者服用环孢素A所致移植后糖尿病的关联分析　出处：《中国临床药理学杂志》2016年20期 　论文类型：期刊论文

【摘要】：目的分析中国骨髓移植患者ABCB1基因型的分布特征及其多态性与中国骨髓移植患者服用环孢素A所致移植后糖尿病的相关性。方法选取中国骨髓移植患者112例为研究对象,其中血糖正常97例和移植后糖尿病15例。用聚合酶链式反应直接测序的方法检测ABCB1各位点的基因型分布及等位基因频率。结果中国骨髓移植患者ABCB1 C1236T、G2677T/A、C3435T基因型分布均符合Hardy-Weinberg平衡。ABCB1 C1236T中移植后糖尿病组和血糖正常组的CC基因型分别为6.67%,14.43%;CT基因型分别为53.33%,45.36%;TT基因型分别为40.00%,40.21%;C等位基因分别为33.33%,37.11%;T等位基因分别为66.67%,62.89%,差异均无统计学意义(P0.05)。ABCB1G2677T/A中移植后糖尿病组和血糖正常组的GG基因型分别为13.33%,9.28%;AG/GT基因型分别为60.00%,52.58%;AA/AT/TT基因型分别为26.67%,38.14%;G等位基因分别为43.33%,35.57%;A/T等位基因分别为56.67%,64.43%,差异均无统计学意义(P0.05)。ABCB1 C3435T中移植后糖尿病组和血糖正常组的CC基因型分别为40.00%,36.08%;CT基因型分别为46.67%,43.30%;TT基因型分别为13.33%,20.62%;C等位基因分别为63.33%,57.73%;T等位基因分别为36.67%,42.27%,差异均无统计学意义(P0.05)。结论 ABCB1多态性与中国骨髓移植患者服用环孢素A所致的移植后糖尿病不相关,但仍不能忽视ABCB1基因多态性对环孢素A药效和药物不良反应的影响。
[Abstract]:Objective to analyze the distribution characteristics and polymorphism of China bone marrow transplantation Chinese bone marrow transplantation in patients with ABCB1 genotype of cyclosporine A induced diabetes after transplantation. Methods we Chinese bone marrow transplantation in 112 patients as the research object, including 15 cases of normal blood glucose and 97 cases of post transplant diabetes mellitus. With the method of direct sequencing of polymerase chain reaction for detection of ABCB1 all the genotype distribution and allele frequency. The results Chinese bone marrow transplantation in patients with ABCB1 C1236T, G2677T/A, C3435T genotype distribution was in accordance with Hardy-Weinberg.ABCB1 equilibrium in C1236T after transplantation, diabetes group and normal blood glucose group and CC genotype were 6.67%, 14.43%; CT genotype were 53.33%, 45.36%; TT gene type were 40%, 40.21%; C alleles were 33.33%, 37.11%; T alleles were 66.67%, 62.89%, there were no significant differences (P0.05.ABCB1G26) 77T/A in the post transplant diabetes mellitus group and normal blood glucose group and GG genotype were 13.33%, 9.28%; AG/GT genotype were 60%, 52.58%; AA/AT/TT genotype were 26.67%, 38.14%; G alleles were 43.33%, 35.57%; A/T alleles were 56.67%, 64.43%, there were no significant differences (P0.05).ABCB1 C3435T in the post transplant diabetes mellitus group and normal blood glucose group and CC genotype were 40%, 36.08%; CT genotype were 46.67%, 43.30%; TT genotype were 13.33%, 20.62%; C alleles were 63.33%, 57.73%; T alleles were 36.67%, 42.27%, there was no difference statistical significance (P0.05). Conclusion ABCB1 polymorphism and China bone marrow transplantation patients taking cyclosporine A induced diabetes after transplantation is not related, but still can not ignore the effect of ABCB1 gene polymorphism on the efficacy and adverse reactions of cyclosporine A drug.

【作者单位】：中国医科大学附属盛京医院药学部;
【基金】：国家自然科学基金项目资助项目(81102517)
【分类号】：R587.1;R457.7
【正文快照】： (中国医科大学附属盛京医院药学部,沈阳110004)He Xiao-Jing(Department of Pharmacy,ShengjingHospital of China Medical University,Shenyang 110004,China)近年来,恶性血液疾病的发病率逐年增加,据估算中国每年新增恶性血液疾病患者约35万。对于恶性血液疾病的治疗除采用

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