脓毒血症患者炎症因子水平与疾病严重程度的关系分析

发布时间：2018-01-01 20:36

本文关键词：脓毒血症患者炎症因子水平与疾病严重程度的关系分析　出处：《中华医院感染学杂志》2016年16期 　论文类型：期刊论文

【摘要】：目的探讨脓毒血症患者降钙素原(PCT)、C-反应蛋白(CRP)和内毒素等炎症因子与其疾病严重程度的关系,为临床治疗提供依据。方法选取医院2011年1月-2015年12月ICU收治的脓毒血症患者160例,分析病原菌分布与炎症因子水平,数据采用SPSS 18.0软件进行统计分析。结果 160例患者共检出160株病原菌,以革兰阴性菌为主,共114株占71.25%;所有患者的CRP、PCT及LPS均与APACHE II评分呈现明显的相关性(P0.05),其中,在革兰阴性菌感染患者中PCT相关性最高;患者PCT、CRP和LPS水平均与疾病的严重程度呈正相关。结论脓毒血症患者炎症因子水平与疾病严重程度呈正相关,为评价患者的病情,评估患者的可能感染类型及早期诊断提供临床参考。
[Abstract]:Objective to investigate the relationship between the severity of the disease and the inflammatory factors such as procalcitonin (PCT) C-reactive protein (CRP) and endotoxin (LPS) in patients with sepsis. Methods 160 patients with sepsis treated in ICU from January 2011 to December 2015 were selected to analyze the distribution of pathogenic bacteria and the level of inflammatory factors. The data were analyzed by SPSS 18.0 software. Results 160strains of pathogenic bacteria were detected in 160patients, mainly Gram-negative bacteria (114strains, 71.25g%). There was a significant correlation between CRPnPCT and LPS and APACHE II score in all patients. Among them, PCT had the highest correlation among Gram-negative bacilli infection patients. Conclusion the level of inflammatory factors in patients with sepsis is positively correlated with the severity of the disease. To evaluate the possible types of infection and early diagnosis of patients provides clinical reference.
【作者单位】：滨州市人民医院ICU;滨州市人民医院呼吸内科;
【基金】：山东省自然科学基金项目资助(2014ZRB14578)
【分类号】：R459.7
【正文快照】： 血流感染是败血症和菌血症的统称,是多种病原菌或真菌侵入人体血流系统所致感染[1]。随着研究的不断深入,人们发现脓毒血症患者体内的炎症因子,如降钙素原(PCT)、C-反应蛋白(CRP)、脂多糖(LPS)等,其与疾病的诊断和严重程度的判断息息相关,但其相应的系统性和相关性的研究较少[

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