2011-2013年综合医院患者铜绿假单胞菌感染与耐药性分析

发布时间：2018-01-01 21:08

本文关键词：2011-2013年综合医院患者铜绿假单胞菌感染与耐药性分析　出处：《中华医院感染学杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的了解综合性医院患者铜绿假单胞菌(PAE)感染的临床分布及对常用抗菌药物的耐药性,为临床医师合理选用抗菌药物提供依据。方法回顾性分析2011年1月-2013年12月医院分离出的798株PAE的分布及耐药性;采用法国生物梅里埃公司的VITEK-32全自动细菌鉴定/药敏分析仪进行细菌鉴定,采用K-B纸片扩散法进行药敏试验,采用WHONET 5.4和SPSS 18.0软件进行统计分析。结果全院2011年1月-2013年12月共分离病原菌5 309株,检出PAE 798株,检出率为15.03%;感染部位以下呼吸道感染最常见;感染科室以呼吸科(包含ICU)、神经科、保健科为主,分别占44.36%、19.05%、18.42%;对PAE耐药率较低的抗菌药物有头孢哌酮/舒巴坦、庆大霉素、阿米卡星、左氧氟沙星,其耐药率20.00%;3年来PAE对常用抗菌药物的耐药率变化,仅对头孢他啶的耐药率呈上升趋势,对其他抗菌药物的耐药性呈下降趋势。结论 PAE引起的医院感染情况严重,应加强对PAE感染率和耐药性的监测,以降低其感染率和耐药性。
[Abstract]:Objective to investigate the clinical distribution of Pseudomonas aeruginosa (PAE) infection and its resistance to common antimicrobial agents in general hospitals. Methods the distribution and drug resistance of 798 strains of PAE isolated from January 2011 to December 2013 were analyzed retrospectively. The bacterial identification was carried out by VITEK-32 automatic bacterial identification / drug sensitivity analyzer, and the susceptibility test was carried out by K-B disk diffusion method. WHONET 5.4 and SPSS 18.0 software were used for statistical analysis. Results A total of 5 309 strains of pathogenic bacteria were isolated from January 2011 to December 2013 in our hospital. 798 strains of PAE were detected and the detection rate was 15.03%. Respiratory tract infection below the infection site was the most common. Respiratory department (including ICUU, Neurology and Health Department) was the main infection department, accounting for 44.36% and 19.05% and 18.42% respectively. Cefoperazone / sulbactam, gentamicin, amikacin and levofloxacin were the antimicrobial agents with low PAE resistance rate of 20.00; In the past three years, the resistance rate of PAE to common antimicrobial agents changed, but only to ceftazidime. Conclusion the situation of nosocomial infection caused by PAE is serious, the surveillance of PAE infection and drug resistance should be strengthened in order to reduce the infection rate and drug resistance of PAE.
【作者单位】：内蒙古医科大学第四附属医院检验科;内蒙古包头医学院第一附属医院检验科;
【基金】：内蒙古自治区高等学校科学研究基金资助项目(NJZY12220)
【分类号】：R446.5
【正文快照】： 铜绿假单胞菌(PAE)广泛分布于水、空气、土壤以及正常人体皮肤、呼吸道与肠道黏膜中,为条件致病菌,因手术、化疗、放疗、激素治疗等原因使人体抵抗力下降时容易引起感染[1]。近年来,各种广谱抗菌药物、免疫抑制剂及激素的使用,导致由PAE引起医院感染率不断升高,并已成为医院感

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