IVIM-DWI成像鉴别兔软组织VX2肿瘤凝固性坏死价值的探讨

发布时间：2018-01-03 19:02

本文关键词：IVIM-DWI成像鉴别兔软组织VX2肿瘤凝固性坏死价值的探讨　出处：《中华肿瘤防治杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的确定软组织肿瘤内有无坏死区对其生物学特性及治疗效果的评估都有着重要的意义。肿瘤内的坏死可为液化性坏死或凝固性坏死,对后者的MRI研究少见。本研究探讨体素内不相干运动弥散加权成像(intravoxel incoherent motion diffusion-weighted imaging,IVIM-DWI)在鉴别兔软组织VX2肿瘤中存活组织与凝固性坏死组织的价值。方法在15只新西兰兔左侧大腿肌肉内接种VX2肿瘤,3周后对其行动态对比剂增强磁共振成像(dynamic contrastenhanced MR imaging,DCE-MRI)和IVIM-DWI成像检查(7个b值,0~800s/mm2)。采用MITK Diffusion软件对IVIM-DWI数据进行处理,形成灌注分数(f值)和真性弥散系数(D值)的参数图。MRI检查完毕后处死实验用兔获取肿瘤标本,在轴位方向上切片,获取与MR轴位图像相对应的大体标本断层组织厚片,并以其为参照,并结合增强早期DCE-MRI在标本对应层面的感兴趣区(region of interest,ROI)测量存活肿瘤组织、凝固性坏死组织的f值和D值。分别采用Wilcoxon秩和检验和独立样本t检验比较存活肿瘤组织与凝固性坏死组织之间D值和f值的差异。结果所有实验用兔的VX2肿瘤均种植成功。共选取51个ROI,其中存活肿瘤组织34个,凝固性坏死组织17个。存活肿瘤组织和凝固性坏死组织的f值分别为(7.995±2.867)%和(5.918±2.709)%,t=2.484,P=0.016。存活肿瘤组织与凝固性坏死组织的D值分别为(1.110±0.110)×10-3和(1.132±0.208)×10-3 mm2/s,Z=0.100,P=0.920。结论由IVIM-DWI所生成的f值能很好地鉴别兔软组织VX2肿瘤中的存活肿瘤组织与凝固性坏死组织,而D值不能鉴别。
[Abstract]:Objective to determine whether there are necrotic areas in soft tissue tumors and to evaluate their biological characteristics and therapeutic effects. Necrosis in soft tissue tumors can be liquefaction necrosis or coagulative necrosis. MRI studies of the latter are rare. In this study, diffusion-weighted imaging of incoherent motion in voxels (. Intravoxel incoherent motion diffusion-weighted imaging. The value of IVIM-DWI in differentiating survival tissue from coagulant necrotic tissue in rabbit soft tissue VX2 tumor. Methods VX2 tumor was inoculated into the left thigh muscle of 15 New Zealand rabbits. After 3 weeks, dynamic contrast agent enhanced dynamic contrastenhanced Mr imaging was performed. DCE-MRI) and IVIM-DWI imaging (7 b values). Using MITK Diffusion software to process IVIM-DWI data. Formation of perfusion fraction (f) and true diffusion coefficient (D). After MRI examination, the rabbits were killed to obtain tumor specimens, and sections were made in the axial direction. The thick sections of the gross specimens corresponding to Mr axial images were obtained and used as a reference. The survival tumor tissue was measured by using the region of interest ROI on the corresponding plane of specimen with enhanced early DCE-MRI. Wilcoxon rank sum test and independent sample t test were used to compare the difference of D value and f value between viable tumor tissue and coagulative necrotic tissue. All the VX2 tumors were successfully implanted in rabbits. 51 ROI were selected. 34 of them survived tumor tissue. There were 17 coagulant necrotic tissues. The f values of surviving tumor tissues and coagulative necrotic tissues were 7.995 卤2.867% and 5.918 卤2.709%, respectively. The D values of survival tumor tissue and coagulative necrosis tissue were 1.110 卤0.110 脳 10-3 and 1.132 卤0.208, respectively. 脳 10-3 mm2/s. Conclusion the f value generated by IVIM-DWI can distinguish survival tumor tissue from coagulant necrotic tissue in rabbit soft tissue VX2 tumor. The D value could not be distinguished.
【作者单位】：中山大学附属第一医院医学影像科;中山市中医院放射科;
【基金】：广东省科技计划(2012B031800071)
【分类号】：R445.2;R738.6
【正文快照】： 中华肿瘤防治杂志,2016,23(9):582-586※在本研究中与第一作者贡献相同slices corresponding to the axial MR images.The values of D and f were measured for the regions of interest(ROIs)ofviable tumor tissue and coagulation necrosis within the tumors,which were

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