替加环素治疗鲍曼不动杆菌感染的Meta分析

发布时间：2018-01-07 16:11

本文关键词：替加环素治疗鲍曼不动杆菌感染的Meta分析　出处：《中国抗生素杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的运用Meta分析方法评价替加环素治疗鲍曼不动杆菌感染的有效性、细菌清除率及不良反应。方法检索中文、英文数据库及医学网站,收集有关替加环素治疗鲍曼不动杆菌感染的临床试验文献,制定纳入排除标准,使用Review Manager 5.3、Stata13软件进行Meta分析。结果最终纳入30篇文献,单用替加环素与其它抗菌药物在总体有效率和细菌清除率方面的对比中,无统计学差异(P0.05)。替加环素联合使用在总体有效率方面明显优于其他抗菌药物(OR=4.24,95%CI3.17~5.68,P0.01),在总体细菌清除率方面也明显优于其他抗菌药物(OR=2.94,95%CI 2.29~3.78,P0.01)。单用替加环素和替加环素联合使用在有效率方面的对比中,替加环素联合使用优于单用替加环素(OR=0.54,95%CI 0.31~0.93,P=0.03),而在细菌清除率方面,两者相比无统计学差异(P0.05)。替加环素组(单用和联合用药)与其它抗菌药物在不良反应方面的对比中,无统计学差异(P0.05)。结论替加环素联合用药治疗鲍曼不动杆菌引起的感染性疾病的效果优于单用替加环素组和其它抗菌药物组,安全性较好。
[Abstract]:Objective to evaluate the efficacy, bacterial clearance and adverse reactions of tigicycline in the treatment of Acinetobacter baumannii infection by Meta. Methods Chinese, English databases and medical websites were searched. To collect the clinical trial literature about tigicycline in the treatment of Acinetobacter baumannii infection, to establish the exclusion criteria and to use Review Manager 5.3. Stata13 software was used for Meta analysis. The results were included in 30 articles and were compared with other antimicrobial agents in the overall effective rate and bacterial clearance. There was no statistical difference (P 0.05). The total effective rate of tegacycline was significantly better than that of other antimicrobial agents ORX 4.2495 CI3.175.68. P0.01A was also superior to other antimicrobial agents in the total bacterial clearance rate, which was 2.94 ~ 95 CI 2.29 ~ 3.78. Compared with tegicycline and tegicycline alone, the combined use of tegacycline was better than that of tegacycline OR0.54. 95 CI 0.31 ~ 0.93P ~ (0.03), but in bacterial clearance rate. There was no statistical difference between the two groups (P 0.05). The adverse reactions of tegacycline group (single and combined use) and other antimicrobial agents were compared. Conclusion the efficacy of tegicycline in the treatment of acinetobacter baumannii infection is better than that of tegacycline alone and other antimicrobial agents.
【作者单位】：西南医科大学护理学院;
【基金】：四川省卫生计生委科研课题(No.140028)
【分类号】：R446.5
【正文快照】： 鲍曼不动杆菌(Acinetobacter baumannii)属革兰阴性杆菌,是一种拥有克隆传播能力、获得性耐药等特点的重要医院感染条件致病菌,多见于ICU患者[1],主要的临床表现为肺炎和菌血症[2]。近年来,随着多重耐药鲍曼不动杆菌(multidrug resistantAcinetobacter baumannii,MDRAB)以及广

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