血必净联合常规西药治疗严重脓毒血症的临床疗效观察

发布时间：2018-01-15 16:40

本文关键词：血必净联合常规西药治疗严重脓毒血症的临床疗效观察　出处：《中药药理与临床》2016年02期 　论文类型：期刊论文

【摘要】：目的:观察研究血必净联合常规西药治疗严重脓毒血症的临床疗效。方法:选取2014年1月至2015年5月我科室收诊疗的诊断为严重脓毒血症的患者80例,按随机数字表法分为实验组及对照组各40例,对照组患者给予单独应用常规西药仙力素抗菌治疗,实验组在对照组常规西药治疗基础上加用血必净治疗,记录并分析治疗后两组患者血清Ca2+及APACHEII评分、利钠肽原(NT-pro BNP)和降钙素原(PCT)变化状况。结果:实验组患者治疗后APACHEII为(13.79±2.36),均明显优于对照组(17.42±3.52);实验组治疗后血清Ca2+、N末端B型利钠肽原(NT-pro BNP)和降钙素原(PCT)分别为(2.15±0.12mmol/L、1031±97.5ng/L、7.53±2.04ug/L),均明显优于对照组(1.68±0.23mmol/L、1792±246.1ng/L、14.02±3.57ug/L)。3实验组患者治疗后白细胞计数和中性粒细胞比例分别为(13.76±1.12×109/L、73.92±1.13%),均明显低于对照组(17.11±1.38×109/L、77.64±1.54%)。4实验组患者恢复情况明显优于对照组。结论:血必净联合常规西药治疗严重脓毒血症疗效确切,与常规治疗相比无明显不良反应。
[Abstract]:Objective: To observe the clinical effect of Xuebijing combined with conventional western medicine in the treatment of severe sepsis. Methods: 80 patients were selected from January 2014 to May 2015 in our department received treatment for the diagnosis of severe sepsis were randomly divided into experimental group and control group 40 cases, given a single application of conventional Western Medicine Cephathiamidin antimicrobial treatment in the control group patients in the experimental group were treated with Xuebijing treatment in the control group received conventional western medicine treatment, recording and analysis of the two groups after treatment of serum Ca2+ and APACHEII score, natriuretic peptide (NT-pro BNP) and procalcitonin (PCT) changes. Results: the experimental group after treatment for APACHEII (13.79 + 2.36), all significantly better than the control group (17.42 + 3.52); experimental group after treatment, serum Ca2+, N terminal B type natriuretic peptide (NT-pro BNP) and procalcitonin (PCT) respectively (2.15 + 0.12mmol/L, 1031 + 97.5ng/L, 7.53 + 2.04ug/L), were significantly Better than the control group (1.68 + 0.23mmol/L, 1792 + 246.1ng/L, 14.02 + 3.57ug/L).3 patients in the experimental group after treatment of white blood cell count and neutrophil percentage were (13.76 + 1.12 * 109/L, 73.92 + 1.13%), were significantly lower than the control group (17.11 + 1.38 * 109/L, 77.64 + 1.54%) was significantly higher than that of.4 the recovery of the experimental group with the control group. Conclusion: Xuebijing injection combined with conventional western medicine in treating severe sepsis treatment, compared with conventional treatment without obvious adverse reactions.

【作者单位】：海南省人民医院;
【基金】：海南省自然科学基金【814322】
【分类号】：R459.7
【正文快照】： 脓毒血症是多继发于其它疾病的一种感染性疾病,该疾病对患者危害非常大,细菌在血液里大量滋生,引起菌血症,感染器官形成器官脓毒症,患者可能因多器官衰竭而死亡[1]。该疾病治疗难度大,主要治疗手段为抗菌消炎治疗,虽然临床有多种抗菌消炎消炎药物,但治疗效果仍不令人满意,患者

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