血小板抗体筛查在多次输血的白血病患者中的应用分析

发布时间：2018-01-15 17:04

本文关键词：血小板抗体筛查在多次输血的白血病患者中的应用分析　出处：《中国输血杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨68例白血病患者血小板抗体的产生与血小板输注次数的关系;血小板输注效果与血小板抗体之间的关系。方法检测68例白血病患者单采血小板输注前后外周血小板计数;以24h CCI值判断血小板输注效果;血小板抗体筛查采用固相凝集法。结果 68例输注单采血小板的患者中共检出抗体阳性13例,阳性率为19.1%,对照组阳性率2.8%,差异具统计学意义;血小板输注次数8次时,血小板抗体的阳性率为(53.3%)分别与输注次数3次组(抗体阳性率8.3%)和输注3-8次组(抗体阳性率10.3%)比较,差异均具统计学意义(P0.05);血小板抗体阴性患者的血小板输注无效率(32.7%)与血小板抗体阳性患者的输注无效率(69.2%)比较,差异具统计学意义(P0.05)。结论随着血小板输注次数的增多血小板抗体检出率明显增高,与输注次数成正相关;血小板抗体阳性与血小板输注无效有相关性。
[Abstract]:Objective to investigate the relationship between platelet antibody production and platelet transfusion in 68 patients with leukemia. Methods Peripheral platelet count was detected in 68 patients with leukemia before and after platelet transfusion. The effect of platelet transfusion was evaluated by 24 h CCI. Results in 68 patients with single platelet transfusion, 13 cases were positive for antibody, the positive rate was 19.1%, and the positive rate of control group was 2.8%. The difference was statistically significant. The number of platelet transfusions was 8 times. The positive rate of platelet antibody was 53.3%, which was compared with the three times of infusion group (8.3%) and the group of 3-8 times infusion (10.3% of antibody positive rate). The difference was statistically significant (P 0.05). The effective rate of platelet transfusion in patients with negative platelet antibody was 32.7g) compared with that in patients with positive platelet antibodies (69.2%). Conclusion with the increase of platelet transfusion times, the detection rate of platelet antibody is obviously increased, and there is a positive correlation between platelet antibody and transfusion times. There was a correlation between platelet antibody positive and platelet transfusion.
【作者单位】：贵州医科大学附属医院输血科;
【分类号】：R457.1+1;;R557
【正文快照】： 血小板输注作为现代成分输血的重要组成部分,被临床广泛用于治疗血小板减少或功能障碍引起出血性疾病[1]。特别是血液方面疾病的患者,由于其疾病本身和或在化疗过程中出现的骨髓受抑制而造成血小板减少时,需输注血小板预防和控制出血。但多次输注血小板或既往有输血史的患者,

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