可溶性髓样细胞触发性受体1、降钙素原、C-反应蛋白在脓毒症中的临床价值

发布时间：2018-01-15 18:11

本文关键词：可溶性髓样细胞触发性受体1、降钙素原、C-反应蛋白在脓毒症中的临床价值　出处：《实用医学杂志》2016年17期 　论文类型：期刊论文

【摘要】：目的:探讨血清可溶性髓样细胞触发性受体1(s TREM-1)、降钙素原(PCT)、C-反应蛋白(CRP)在脓毒症中的临床价值。方法:采用前瞻性研究方法收集相关患者的临床资料,并采用ELISA检测39例脓毒症患者、15例全身炎症反应综合征(SIRS)患者和12例正常对照组。通过分析3种因子对判断脓毒症患者预后的价值。结果:脓毒症组与SIRS组中血清s TREM-1及PCT水平明显高于对照组(P0.05),而CRP只在脓毒症组与对照组中差异有统计学意义(P0.05);脓毒症组中s TREM-1、PCT及CRP均明显高于SIRS组(P0.05)。根据ROC曲线分析,s TREM-1、PCT及CRP对SIRS和非SIRS进行诊断的曲线下面积分别为0.914、0.887和0.831。结论:血清s TREM-1是脓毒症早期诊断的较好指标,同时具有较高的灵敏度和特异度。
[Abstract]:Objective: to investigate the serum soluble myeloid cell trigger receptor (TREM-1) and procalcitonin (PCT). Clinical value of C-reactive protein (CRP) in sepsis methods: prospective study was used to collect clinical data of patients with sepsis and 39 patients with sepsis were detected by ELISA. 15 cases of systemic inflammatory response syndrome (SIRS). The prognostic value of three factors in sepsis patients was analyzed. Results: serum s in sepsis group and SIRS group. The levels of TREM-1 and PCT were significantly higher than those of the control group (. P0.05). However, the difference of CRP between sepsis group and control group was statistically significant (P 0.05). In sepsis group, s TREM-1 and CRP were significantly higher than those in SIRS group (P 0.05). ROC curve was used to analyze TREM-1. The area under the curve of SIRS and non-#en3# diagnosed by PCT and CRP were 0.914, respectively. Conclusion: serum s TREM-1 is a good index for the early diagnosis of sepsis, and has high sensitivity and specificity.
【作者单位】：广东省韶关市粤北人民医院重症医学科;广东省韶关市粤北人民医院产科;广东省韶关市粤北人民医院检验科;
【基金】：广东省韶关市科技局课题(编号:Y15033)
【分类号】：R459.7
【正文快照】： 脓毒症(sepsis)是由感染引起的全身炎症反应综合征,可发展为严重脓毒症(severe sepsis)和脓毒性休克(septic shock)。严重脓毒症和脓毒性休克是重症医学面临的重要临床问题,随着人口的老龄化、肿瘤发病率上升及侵入性医疗手段的增加,脓毒症的发病率在不断上升,每年全球新增数

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