重庆地区2014年幽门螺杆菌临床分离株耐药性分析

发布时间：2018-01-17 17:05

本文关键词：重庆地区2014年幽门螺杆菌临床分离株耐药性分析　出处：《中国药房》2016年11期 　论文类型：期刊论文

【摘要】：目的:了解重庆地区幽门螺杆菌(Hp)临床分离株对常用抗菌药物的体外敏感性及耐药性,并分析耐药原因。方法:Hp菌株取自重庆地区4家医院2014年4-12月胃镜室,随机取患者胃黏膜活检标本189例,分离培养后进行体外抗菌药物敏感性试验,检测Hp对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星、四环素、呋喃唑酮的敏感性,并与2005年数据进行对比。同时问卷调查医师在Hp治疗中抗菌药物的选择倾向性。结果:共培养出Hp 63株,其对甲硝唑、克拉霉素、阿莫西林、左氧氟沙星、四环素及呋喃唑酮的耐药率分别为100%、28.6%、0、34.9%、0、0。28.6%的菌株同时对甲硝唑及克拉霉素耐药。Hp对甲硝唑的耐药率较2005年有所升高,对呋喃唑酮的耐药率有所降低,差异均有统计学意义(P0.05)。医师在Hp治疗中抗菌药物选择倾向最高的为阿莫西林+克拉霉素(42.8%)。结论:重庆地区Hp对甲硝唑、克拉霉素及左氧氟沙星的耐药率较高,这可能与医师选择倾向及同种属抗菌药物大量使用相关。建议重庆地区Hp治疗可选用阿莫西林、呋喃唑酮及四环素。
[Abstract]:Objective: to investigate the in vitro sensitivity and drug resistance of clinical isolates of Helicobacter pylori (HP) to common antimicrobial agents in Chongqing. Methods A total of 189 gastric mucosa biopsies were randomly collected from 4 hospitals in Chongqing from April to December of 2014. The sensitivity of HP to metronidazole, clarithromycin, amoxicillin, levofloxacin, tetracycline and furazolidone was tested. Results: 63 strains of HP were cultured with p-metronidazole, clarithromycin and amoxicillin. The drug resistance rates of levofloxacin, tetracycline and furazolidone were 100% and 28.6%, respectively. The resistance rate of 0.28.6% strains to metronidazole and clarithromycin. HP to metronidazole was higher than 2005, and the resistance rate to furazolidone was lower. Amoxicillin clarithromycin 42.8. Conclusion: HP p-metronidazole in Chongqing area. Clarithromycin and levofloxacin have high drug resistance, which may be related to the choice of doctors and the extensive use of the same antimicrobial agents. It is suggested that amoxicillin, furazolidone and tetracycline can be used for HP treatment in Chongqing area.
【作者单位】：重庆医科大学附属第二医院消化内科;
【分类号】：R446.5
【正文快照】： 幽门螺杆菌(Helicobacter pylori,Hp)为定植于人胃黏膜的一种微需氧、螺旋状的革兰阴性杆菌,已被公认为是慢性胃炎、胃十二指肠溃疡的重要病因,并与胃癌、胃黏膜相关性淋巴样组织淋巴瘤(MALT)的发生密切相关。Hp的分离培养较为困难,因此针对其耐药性的分析报道较少。既往仅有

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