慢性鼻-鼻窦炎伴或不伴鼻息肉患者细菌培养及药敏试验分析

发布时间：2018-01-20 17:18

本文关键词： 慢性鼻-鼻窦炎细菌培养抗菌药物　出处：《临床耳鼻咽喉头颈外科杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的:了解慢性鼻-鼻窦炎(CRS)伴(或不伴)鼻息肉患者窦腔分泌物的细菌培养及药敏试验情况。方法:收集175例CRS伴(或不伴)鼻息肉患者窦腔内分泌物进行细菌培养和药敏试验,分析细菌菌群分布的特点及敏感药物。结果:送检标本175例,检出致病菌118株,阳性率为67%。其中革兰氏阳性菌菌株79株,革兰氏阴性菌菌株39株。革兰氏阳性菌中最常见病原菌为表皮葡萄球菌、金黄色葡萄球菌、溶血葡萄球菌。革兰氏阴性菌中最常见病原菌为铜绿假单胞菌、产气肠杆菌、阴沟肠杆菌。对革兰氏阳性菌敏感率较高的抗生素分别为:阿米卡星、达托霉素、利奈唑胺、万古霉素、替考拉宁、阿莫西林克拉维酸钾、头孢呋辛。对革兰氏阴性菌敏感率较高的抗生素分别为:阿米卡星、头孢哌酮(舒巴坦)、亚胺培南、头孢他啶、氨曲南、左氧氟沙星。结论:CRS伴(或不伴)鼻息肉患者多数窦腔内存在细菌感染。其中革兰氏阳性菌为主要致病菌。革兰氏阳性菌及革兰氏阴性菌在抗生素敏感度上存在很大的差异,需根据细菌培养及药敏试验选用敏感抗生素。
[Abstract]:Objective: to investigate the bacterial culture and drug sensitivity test of sinus secretion from patients with (or without) nasal polyps in chronic rhinosinusitis. Methods: 175 cases of CRS with (or without) nasal polyps were collected. Bacterial culture and drug sensitivity test were performed in sinusoidal secretion of patients with nasal polyps. The distribution of bacteria and sensitive drugs were analyzed. Results: among 175 samples, 118 pathogenic bacteria were detected, and the positive rate was 67. Among them, 79 were Gram-positive strains. The most common pathogens of Gram-positive bacteria were Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus haemolyticus, and Pseudomonas aeruginosa were the most common pathogens of Gram-negative bacteria. Enterobacter aerogenes, Enterobacter cloacae. The antibiotics with high sensitivity to Gram-positive bacteria were: amikacin, datromycin, linazolamine, vancomycin, teicoplanin, amoxicillin and potassium clavulanate. Cefuroxime. The antibiotics with high sensitivity to Gram-negative bacteria were: amikacin, cefoperazone (sulbactam, imipenem, ceftazidime, aztreonam). Levofloxacin. Conclusion: 1. CRS with (or without). Bacterial infection exists in most nasal polyp patients. Gram-positive bacteria are the main pathogenic bacteria. There are great differences in antibiotic sensitivity between Gram-positive bacteria and Gram-negative bacteria. Sensitive antibiotics should be selected according to bacterial culture and drug sensitivity test.
【作者单位】：白求恩国际和平医院耳鼻咽喉头颈外科;
【分类号】：R446.5
【正文快照】： 慢性鼻-鼻窦炎(chronic rinosinisitis,CRS)伴(或不伴)鼻息肉是耳鼻喉科的常见疾病,严重的影响着患者生活质量。尽管目前研究提示细菌感染不是主要致病因素。但临床实践过程仍广泛使用抗生素治疗CRS。关于CRS患者鼻腔、鼻窦的细菌学研究近年来国内外均有不少报道,但国内外研究

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