河北省2014年43株侵袭性肺炎链球菌血清型分析

发布时间：2018-01-24 02:37

本文关键词： 肺炎链球菌侵袭性肺炎链球菌疾病血清型　出处：《中国疫苗和免疫》2016年01期 　论文类型：期刊论文

【摘要】：目的利用分子生物学方法了解河北省侵袭性肺炎链球菌血清型的流行特征。方法收集河北省儿童医院的43株侵袭性肺炎链球菌,应用聚合酶链反应(Polymerase Chain Reaction,PCR)检测cps A基因确定种属,应用多重PCR检测血清型。结果在43株侵袭性肺炎链球菌中,19F型11株(25.58%),19A型7株(16.27%)、6A/6B型6株(13.95%)、14型5株(11.62%)、1型4株(9.30%),其余血清型数量较少。结论河北省侵袭性肺炎链球菌的血清型别呈现多样性特点,19F型和19A型为主要血清型别。建议结合优势血清型、针对不同人群特点合理应用肺炎链球菌疫苗,同时应关注肺炎链球菌血清型替换现象。
[Abstract]:Objective to investigate the epidemic characteristics of Streptococcus pneumoniae serotype in Hebei Province by molecular biological method. Methods 43 strains of Streptococcus pneumoniae were collected from Hebei Children's Hospital. Polymerase chain reaction (PCR) was used to detect the cps A gene. Results among 43 strains of invasive Streptococcus pneumoniae, 11 strains (25.58A) were detected by multiplex PCR. There were 6 strains of 6A / 6B (13.95%) and 5 strains of type 14 (11.622), and 4 strains of type 1 (9. 30). Conclusion the serotype of Streptococcus pneumoniae invasively in Hebei Province shows diversity characteristics: 19F and 19A are the main serotypes. It is suggested to combine the dominant serotype. We should pay attention to the serotype replacement of Streptococcus pneumoniae at the same time according to the characteristics of different population and the rational use of Streptococcus pneumoniae vaccine.
【作者单位】：河北省疾病预防控制中心;河北省儿童医院;
【基金】：河北省科技支撑计划项目(No.14277733D)
【分类号】：R446.5;R725.6
【正文快照】： 肺炎链球菌(Streptococcus pneumoniae,Sp)是引起儿童感染最常见的病原菌,不仅可引起鼻窦炎、中耳炎、肺炎等非侵袭性感染,还可引起严重的脓毒血症、化脓性脑膜炎、菌血症性肺炎等侵袭性肺炎链球菌疾病(Invasive Pneumococcal Disease,IPD)。相对于非侵袭性感染,IPD往往病情较

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