ICU感染患者血清PCT、TNF-α、急性期相应的反应蛋白变化与预后的相关性研究

发布时间：2018-01-30 08:04

本文关键词： ICU感染患者血清 PCT TNF-α 急性期相应的反应蛋白　出处：《中华医院感染学杂志》2016年24期 　论文类型：期刊论文

【摘要】：目的研究ICU感染患者血清PCT、TNF-α、急性期相应的反应蛋白的变化及与预后的关系,为ICU患者感染的防控与治疗提供参考依据。方法选取2014年7月-2016年4月34例ICU感染患者为观察组,并选取同时期34例ICU未发生感染的患者为对照组,比较两组患者血清PCT、TNF-α、急性期相应的反应蛋白,比较两组中存活者与死亡者的检测结果、不同感染部位与病原菌感染情况。结果观察组血清PCT、TNF-α、急性期相应的反应蛋白均高于对照组;观察组死亡者与存活者均高于对照组,差异均有统计学意义(P0.05)。结论 ICU感染患者血清PCT、TNF-α、急性期相应的反应蛋白的表达水平相对较高,且其表达水平对患者的预后有积极的临床价值。
[Abstract]:Objective to study the changes of serum levels of TNF- 伪 and reactive protein in patients with ICU infection and their relationship with prognosis. Methods 34 patients with ICU infection from July 2014 to April 2016 were selected as the observation group. 34 patients without ICU infection in the same period were selected as the control group. The serum levels of TNF- 伪 and the corresponding reactive protein in acute phase were compared between the two groups. Results the serum levels of PCT TNF- 伪 and the corresponding reactive protein in acute phase were higher in the observation group than in the control group. Both the dead and the survivors in the observation group were higher than those in the control group, and the difference was statistically significant (P 0.05). Conclusion the serum levels of ICU TNF- 伪 in patients with ICU infection are significantly higher than those in the control group. The expression level of reactive protein in acute stage is relatively high, and its expression level has positive clinical value for the prognosis of patients.
【作者单位】：厦门大学附属第一医院重症医学科;厦门大学附属第一医院呼吸内科;
【基金】：福建省自然科学基金青年课题(J00162)
【分类号】：R459.7
【正文快照】： ICU是感染的高发区,与本科室患者的疾病特点及其他因素有较大的关系,而本科室感染的控制也一直是临床研究的重点,临床相关研究虽较为常见[1-2],但是关于此类患者感染发生发展过程中的机体应激尤其是感染应激相关指标的研究仍十分不足,因此对于这些指标的研究掌握极为必要。本

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