肿瘤病人肠外营养导致中心静脉导管相关感染的研究进展

发布时间：2018-02-08 12:36

本文关键词： 肿瘤胃肠外营养中心静脉导管中心静脉导管相关感染生物膜混合生物膜免疫荧光杂交技术肠外营养液　出处：《肠外与肠内营养》2016年02期 　论文类型：期刊论文

【摘要】：随着肿瘤病人肠外营养(PN)和中心静脉导管的广泛应用,中心静脉导管相关性感染已成为临床令人棘手的常见院内感染。在PN输注过程中,PN液在中心静脉导管周围形成高糖和高脂微环境,有利于病原菌在置入的中心静脉导管表面黏附、生长和扩散,形成由一种或多种病原菌组成的细菌生物膜。一旦细菌生物膜形成,膜内的病原菌可抵御抗菌药物及机体免疫细胞的杀伤,造成细菌或真菌反复感染,危及病人生命。以下综述PN的应用、肿瘤病人中心静脉导管感染的特点、混合生物膜及其研究方法等,以期对中心静脉导管相关混合生物膜感染的研究提供参考。
[Abstract]:With the extensive use of parenteral nutrition (PNs) and central venous catheters in cancer patients, Central Venous Catheter-Related infection has become a common nosocomial infection in clinic. During PN infusion, PN solution forms high glucose and fat microenvironment around the central venous catheter. A bacterial biofilm consisting of one or more pathogens is formed by facilitating the adhesion, growth and diffusion of pathogenic bacteria on the surface of the inserted central venous catheter. Once the bacterial biofilm is formed, The pathogenic bacteria in membrane can resist the killing of antimicrobial agents and immune cells, causing repeated infection of bacteria or fungi and endangering the life of patients. This paper summarizes the application of PN and the characteristics of central venous catheter infection in tumor patients. The mixed biofilm and its research methods are expected to provide reference for the study of central venous catheter related mixed biofilm infection.
【作者单位】：昆明医科大学第三附属医院/云南省肿瘤医院胸外科;
【基金】：国家自然科学基金资助项目(81260228) 云南省科技计划项目(2014NS002)
【分类号】：R730.5;R459.3

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