中老年回汉族人群胰岛素抵抗及β细胞功能与脂代谢的关系

发布时间：2018-02-12 10:41

本文关键词： 胰岛素抵抗指数 β细胞功能指数体质量指数腰臀比胆固醇三酰甘油　出处：《中国医学科学院学报》2016年02期 　论文类型：期刊论文

【摘要】：目的对宁夏城市社区回汉族中老年人群的胰岛素抵抗及β细胞功能与体质量指数及血脂等影响因素进行关联性对比研究。方法选取宁夏城市地区40岁以上的社区调查者共1 000例,回汉比例1∶2。测量身高、体质量、腰围、臀围;三酰甘油(TG)、总胆固醇(TC)、血尿酸(BUA)、血糖、胰岛素,计算体质量指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(IR)、胰岛素敏感指数(IAI)、β细胞功能指数(HBCI)。结果回族的BMI、WHR、IAI、HBCI和糖尿病的患病比例均显著高于汉族(P0.01),但是BUA、血糖、TC、IR均低于回族(P0.01)。回族中TG、BMI、WHR、BUA与IR呈正相关(r分别为0.234、0.193、0.143、0.129,P0.01),与IAI呈负相关(r分别为-0.234、-0.193、-0.143、-0.129,P0.01),TC与HBCI呈负相关(r为-0.169,P0.01);汉族中TC、TG、BMI、WHR、BUA均与IR呈正相关(r分别为0.140、0.257、0.288、0.163、0.104,P0.01),与IAI呈负相关(r分别为-0.140、-0.257、-0.288、-0.163、-0.104,P0.01),BMI与HBCI呈负相关(r为-0.111,P0.01)。校正性别、民族、年龄因素后,TC、TG、BMI、WHR、BUA均与IR呈正相关(r分别为0.109、0.256、0.253、0.139、0.142,P0.01),与IAI呈负相关(r分别为-0.109、-0.256、-0.253、-0.139、-0.142,P0.01),TC、BMI与HBCI呈负相关(r=-0.113,r=-0.086,P0.01)。多元回归分析显示TG、BMI与IR、IAI独立相关(r分别为0.218、0.182、-0.218、-0.182),TC、BMI与HBCI独立相关(r分别为-0.113、-0.086)。结论宁夏地区中老年人TC、TG、BMI、WHR、BUA和IR、IAI、HBCI的分布特征及其之间的关系存在着回汉族差异。校正性别、民族、年龄因素后,BMI、WHR、TC、TG、BUA与IR、IAI显著相关,BMI、TC与HBCI显著相关,TC、BMI可能对β细胞的分泌功能影响较大,而TG、BMI则主要与胰岛素抵抗及胰岛素敏感性相关。
[Abstract]:Objective to study the correlation between insulin resistance, 尾 cell function and body mass index (BMI) and serum lipids in middle and old population of Han nationality in urban community of Ningxia. Methods the community over 40 years old in urban area of Ningxia was selected to study the correlation between insulin resistance and 尾 cell function. A total of 1,000 cases were investigated, Measurements of height, body mass, waist circumference, hip circumference, triglyceride TGG, total cholesterol TCU, blood uric acid BUAA, blood glucose, insulin, The body mass index (BMI), waist hip ratio (WHR), insulin resistance index (IR), insulin sensitivity index (IIA), 尾 cell function index (尾) were calculated. Results the prevalence rates of BMIWHRIAIHBCI and diabetes in Hui nationality were significantly higher than those in Han nationality (P 0.01), but the blood glucose TCIR in BUAs was lower than that in Hui nationality (P 0.01). In the Hui nationality, the positive correlation r between TGBMI-WHRBUA and IR was 0.2340.193, 0.1430.129P0.01, respectively, and the negative correlation with IAI was -0.234- 0.193- 0.143- 0.129P0.01TC was negatively correlated with HBCI (r = -0.169P0.01a); in the Han nationality, the positive correlation r between TGG and IR was 0.1400.2570.2870.104P0.01and the negative correlation with IAI was -0.250- 0.28-0.163- 0.103- 0.1040.01and 0.111r respectively. The nation, After age factor, the positive correlation r between TGBMI and IR was 0.109 / 0.2560.1390.1390.142P0.01, and the negative correlation between TGBMI and IAI was -0.109- 0.256- 0.253- 0.139- 0.142TCQ and HBCI were negatively correlated r-0.113r-0.086P0.01.The multiple regression analysis showed that the independent correlation r between TGBMI and HBCI was 0.2182m-1 -0.2182a -0.2182T / HBCI, r = -0.11386-0.086.Conclusion multiple regression analysis showed that the independent correlation r between TGBMI and HBCI was -0.11386- 0.086.Conclusion multiple regression analysis showed that the independent correlation between TGBMI and HBCI was 0.2182a -0.2182a -0.2182a, respectively. Conclusion the correlation between TGBMI and HBCI is negative correlation r = -0.11386- 0.086.Conclusion Multivariate regression analysis shows that the correlation between TGBMI and HBCI is negative. The distribution characteristics and the relationship between TCU TGM BMIR Bua and IIA HBCI in the middle and old people in Xia area were different from those in Han nationality. There was a significant correlation between BMIT, TGG, Bua and IRI. BMITC and HBCI significantly correlated with 尾 cell secretory function, while TGN BMI was mainly related to insulin resistance and insulin sensitivity.
【作者单位】：宁夏医科大学研究生院;宁夏医科大学总医院暨生物芯片北京国家工程研究中心宁夏分中心;宁夏医科大学公共卫生学院流行病与卫生统计学系;宁夏医科大学总医院体检中心;
【基金】：国家自然科学基金(81160049)~~
【分类号】：R446.112

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