偏头痛患者针刺足临泣对疼痛相关脑功能网络影响的fMRI研究

发布时间：2018-02-22 09:05

本文关键词： 偏头痛针刺足临泣疼痛网络静息态功能磁共振成像技术　出处：《中华中医药杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的:探讨疼痛相关脑功能网络层面的偏头痛发病机制及针刺足临泣的穴位特异性效应机制。方法:选择符合标准的偏头痛患者15例和健康受试者13名进行静息态和针刺足临泣状态功能磁共振扫描,分别对比分析偏头痛患者与健康受试者及其针刺前后的疼痛相关脑区之间的功能连接度。结果:针刺前与针刺后,偏头痛患者与健康受试者比较,主要在左侧海马旁回、右侧(双侧)后扣带回及左侧角回的功能连接度均减弱;针刺后较针刺前,健康受试者在左侧海马旁回、缘上回、扣带回中部及岛叶等脑区的功能连接度减弱,而在右侧海马、右侧前扣带回及左侧杏仁核与左侧海马则增强;偏头痛患者针刺后较针刺前,则双侧中央后回、右侧海马旁回,双侧扣带回中部及左侧缘上回等脑区的功能连接度均不同程度增强。结论:偏头痛患者在疼痛相关网络的脑区功能连接度减弱,针刺足临泣后相关脑区功能连接度增强,可能分别为偏头痛的发病机制及针刺足临泣的即刻效应机制。
[Abstract]:Objective: to investigate the pathogenesis of migraine at the level of pain related brain function network and the mechanism of acupoint specific effect of acupuncture on foot sobs. Methods: 15 patients with migraine and 13 healthy subjects were selected for rest. Functional Magnetic Resonance Imaging (fMRI) of state and needle-prick foot sobbing state, The degree of functional connectivity between migraine patients and healthy subjects and the pain related brain regions before and after acupuncture were compared. Results: before and after acupuncture, migraine patients were compared with healthy subjects in left hippocampal gyrus. The functional connections of the right (bilateral) posterior cingulate gyrus and the left horn gyrus were weakened, and the functional connectivity of the left pariprahippocampal gyrus, superior marginal gyrus, middle cingulate gyrus and the insular lobe of the right hippocampal gyrus was weakened in the healthy subjects, but in the right hippocampus. The right anterior cingulate gyrus, left amygdala and left hippocampus were increased. The functional connectivity of the middle cingulate gyrus and the left superior marginal gyrus was enhanced in different degrees. Conclusion: the functional connectivity of the brain regions in patients with migraine is weakened in the pain related network, and the functional connectivity of the related brain regions is enhanced after acupuncture. It may be the pathogenesis of migraine and the immediate effect of acupuncture on sobs.
【作者单位】：北京中医药大学东直门医院;北京市鼓楼中医医院;
【基金】：北京市高校青年英才计划课题(No.YETP0723) 北京中医药大学自主选题资助项目(No.2015-JYB-XS146)~~
【分类号】：R445.2;R246.6

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