降钙素原对不同热程发热儿童严重细菌感染诊断价值的系统评价

发布时间：2018-03-01 01:05

本文关键词： 降钙素原发热热程严重细菌感染系统评价　出处：《新疆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：探讨降钙素原(PCT)对不同热程发热儿童严重细菌感染(SBIs)的诊断价值。方法：计算机检索获得PCT对发热儿童严重细菌感染诊断价值的文献,检索时间为建库至2014年7月,按照QUAD AS标准对纳入文献进行质量评估。使用MetaDisc1.4软件进行Meta分析,对不同平均热程(24、～48和48h)PCT、WBC和中性粒细胞绝对计数(ANC)诊断SBIs的敏感度、特异度等指标进行汇总,并进行异质性检验,绘制综合受试者工作特征曲线(SROC),计算曲线下面积(AUC)。使用Stata12.0软件判断发表偏倚并绘制漏斗图。结果：初检到442篇文献,11篇文献符合纳入标准进入Meta分析(中文1篇,英文10篇)。①平均热程24h对SBIs的诊断价值：PCT的汇总敏感度和特异度分别为0.75和0.80,SROC AUC为0.870；WBC的汇总敏感度和特异度分别为0.48和0.54,AUC为0.484;ANC的汇总敏感度和特异度分别为0.30和0.78。②平均热程24～48h对SBIs的诊断价值：PCT的汇总敏感度和特异度分别为0.86和0.63,AUC为0.857；WBC的汇总敏感度和特异度分别为0.54和0.46,AUC为0.558；ANC的汇总敏感度和特异度分别为0.47和0.12。③平均热程48h对SBIs的诊断价值：PCT的汇总敏感度和特异度分别为0.83和0.55,AUC为0.816；2篇WBC文献的敏感度特分别为0.69和0.34,特异度分别为0.81和0.29；ANC的敏感度和特异度分别为0.87和0.40。结论：对发热儿童诊断SBIs的价值,发热24检测PCT有较高的特异度；发热24-48h检测PCT有较高的敏感度。
[Abstract]:Objective: to investigate the diagnostic value of procalcitonin in the diagnosis of severe bacterial infection in children with fever of different fever course. Methods: the literature of PCT in the diagnosis of severe bacterial infection in febrile children was retrieved by computer, and the retrieval time was up to July 2014. The quality of the literature was evaluated according to the QUAD as standard. The sensitivity and specificity of different mean caloric cycles (24 ~ 48 and 48 h) and the absolute count of neutrophils (ANC) in the diagnosis of SBIs were summarized by Meta analysis with MetaDisc1.4 software. And test the heterogeneity, Using Stata12.0 software to judge publication bias and draw funnel diagram. Results: the first 442 articles and 11 articles met the inclusion criteria and entered the Meta analysis (1 in Chinese, 1 in Chinese), and 11 in accordance with the inclusion criteria (1 in Chinese, 1 in Chinese, 1 in Chinese) and 11 in accordance with the inclusion criteria (1 in Chinese, 1 in Chinese, 1 in Chinese) and 11 in accordance with the inclusion criteria. Diagnostic value of mean caloric duration for 24 hours in SBIs: the aggregate sensitivity and specificity of SBIs were 0.75 and 0.80, respectively. The sum sensitivity and specificity of AUC were 0.48 and 0.54, respectively, and the sum sensitivity and specificity of 0.484A were 0.30 and 0.30, respectively. Diagnostic value of mean caloric duration for SBIs in 48h the aggregate sensitivity and specificity of SBIs were 0.86 and 0.63, respectively. The aggregate sensitivity and specificity were 0.54 and 0.466, respectively. The sum sensitivity and specificity of SBIs were 0.47 and 0.12.3, respectively. Diagnostic value of 48h for SBIs the aggregate sensitivity and specificity of WBC were 0.83 and 0.55AUC, 0.816AUC, 0.69 and 0.34, respectively, and the sensitivity and specificity of WBC were 0.81 and 0.29, respectively. Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40.Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40.Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40.Conclusion: the sensitivity and specificity of WBC are 0.87 and 0.40 respectively. The diagnostic value of SBIs in children with fever, Febrile 24 had higher specificity for PCT and 24-48 h for PCT.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R446.5

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