稀有血型结肠癌患者紧急抢救输血病例分析1例

发布时间：2018-03-01 16:30

本文关键词： 肿瘤不规则抗体紧急抢救输血　出处：《中国输血杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨1例稀有血型结肠癌患者紧急抢救输血时因不规则抗体存在导致交叉配血困难而采用特殊情况紧急抢救输血推荐方案的可行性。方法标本首次血型检测采用全自动血型仪检测血型(微孔板法),并用试管法复查患者血型;微柱凝胶抗球蛋白法、盐水法、聚凝胺法、试管抗人球蛋白法做抗体筛查和交叉配血。结果患者血型为A型,Rh表型为ccDEE型,血清中含有抗-C和抗-e不规则抗体;经过Rh表型筛选,从O型供者中找到Rh表型为ccDEE悬浮红细胞1 U,从浙江省血液中心的A型供者中筛查到Rh表型为ccDEE悬浮红细胞3 U,输注后12 h检测血红蛋白61 g/L,提示输注有效。有效地缓解了患者的贫血症状,无输血不良反应。结论对于因不规则抗体存在导致配血困难而又需紧急输血抢救的肿瘤患者,在ABO血型同型无法满足供应时,可筛选O型Rh表型一致且交叉配血试验阴性的供者红细胞输注。
[Abstract]:Objective to investigate the feasibility of using the recommended scheme of emergency rescue transfusion in a case of colon cancer with rare blood group because of the difficulty of cross matching caused by irregular antibody. Methods the blood group of a sample was detected for the first time. The blood group was detected by automatic blood type instrument (micropore plate method, and the blood group of patients was re-examined by test tube method). Microcolumn gel anti-globulin method, brine method, polyagglutination method, and test tube anti-human globulin method were used for antibody screening and cross-matching. Results the blood group of the patients was ccDEE phenotype, and there were anti-C and anti-e irregular antibodies in serum. After Rh phenotypic screening, The Rh phenotype was found to be ccDEE suspended erythrocyte 1U in O donors, and the Rh phenotype was found to be ccDEE suspended erythrocyte 3U from A donors in Zhejiang Blood Center. Hemoglobin 61g / L was detected 12 hours after infusion, indicating that the transfusion was effective. Effectively alleviated the patient's anemia symptoms, Conclusion for the tumor patients who have difficulty in matching blood caused by irregular antibodies and need emergency blood transfusion, when the ABO blood group is homotypic can not meet the supply, Donors with identical O type Rh phenotype and negative cross matching test could be screened for erythrocyte transfusion.
【作者单位】：杭州市下沙医院;浙江大学医学院附属邵逸夫医院;解放军总医院;南方医科大学南方医院;
【分类号】：R735.35;R457.1

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