梅毒螺旋体抗体筛查反应性献血者归队策略研究

发布时间：2018-03-01 23:37

本文关键词： 献血者归队献血者屏蔽抗-TP假阳性灰区 ELISA TPPA　出处：《中国输血杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的制定梅毒螺旋体抗体(抗-TP)筛查反应性献血者归队策略。方法收集全国12家采供血机构2013年12月-2015年6月抗-TP ELISA筛查反应性献血者标本373例,经ELISA、TPPA确证检测或/和8周后追踪检测,鉴别这些献血者抗-TP是否为真(假)阳性,确定其是归队还是继续屏蔽。结果在373例抗-TP筛查反应性标本中,确证(经确证试验和/或追踪)抗-TP阳性145例(38.9%,145/373)、不确定4例,此149名献血者可作暂时性屏蔽;抗-TP阴性114例(30.6%,114/373),其献血者可以归队;110例(29.5%,110/373)因未成功追踪而被放弃。结论抗-TP筛查反应性献血者的归队策略:确证试验ELISA有反应性、TPPA为阳性者,判为抗-TP阳性,暂时性屏蔽;确证试验ELISA有(或无)反应性而TPPA是阴性,8周后追踪检测。
[Abstract]:Objective to establish a strategy for screening reactive blood donors with Treponema pallidum antibody (anti-TP). Methods from December 2013 to June 2015, a total of 373 anti-TP ELISA samples were collected from 12 blood collection institutions in China. After confirmed by ELISAN TPPA or / and followed up for 8 weeks, the blood donors were identified as true (false) positive for anti-TP and whether they were returned to the team or continued to be shielded. Results in 373 samples of anti-TP reactivity, 145 cases of anti-TP positive were confirmed (confirmed test and / or follow up), including 148.5% 373U, and 4 cases were uncertain. The 149 blood donors could be temporarily shielded. The blood donors of 114 patients with negative anti-TP were given up because of unsuccessful follow-up. Conclusion the return strategy of anti-TP screening reactive blood donors: it was confirmed that the patients who were positive for ELISA were found to be positive for anti-TP, and those who were found to be positive for anti-TP were found to be positive for anti-TP and temporarily shielded. It was confirmed that ELISA was (or was not) reactive and TPPA was negative for 8 weeks.
【作者单位】：中国医学科学院
【基金】：2013年国家卫生和计划生育委员会委托项目(这个委托项目没有基金编号) 协和青年基金(3332015121)
【分类号】：R446.61

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