DCE-MRI定量参数与直肠癌病理分期及分级的相关性研究

发布时间：2018-03-04 14:48

本文选题：直肠癌　切入点：磁共振成像　出处：《临床放射学杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的探讨动态增强磁共振成像(DCE-MRI)定量参数与直肠癌T分期、淋巴结转移及肿瘤分化程度的相关性。方法连续搜集本院2012年12月21日至2015年8月3日符合纳入标准的原发直肠癌患者91例,术前行常规MRI及DCE-MRI扫描,测量DCE-MRI定量参数[转运常数(K~(trans))、速率常数(K_(ep))、容积分数(V_e)值],并分析与直肠癌T分期、淋巴结转移、肿瘤分化程度的关系。结果 K~(trans)、K_(ep)、V_e与直肠癌T分期存在正相关(r=0.758,P=0.000;r=0.395,P=0.000;r=0.314,P=0.002);K~(trans)及K_(ep)在有无转移淋巴结组之间比较有显著性差异(t=6.893,P=0.000;t=3.355,P=0.001);K~(trans)、V_e与肿瘤分化程度存在负相关(r=-0.223,P=0.034;r=-0.259,P=0.013)。结论 DCE-MRI药代动力学定量参数与直肠癌T分期及淋巴结转移、肿瘤分化程度存在一定的相关性,定量参数可以为直肠癌的临床预后提供一定的参考价值。
[Abstract]:Objective to study the quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) and T stage of rectal cancer. Methods from December 21st 2012 to August 3rd 2015, 91 patients with primary rectal cancer who met the inclusion criteria were continuously collected. Routine MRI and DCE-MRI scans were performed before operation. The quantitative parameters of DCE-MRI were measured, and the T stage and lymph node metastasis of rectal cancer were analyzed. Results there was a positive correlation between KT T stage and T stage of rectal cancer. Results there was a positive correlation between KT and T stage of rectal cancer. Results there was a negative correlation between the level of tumor differentiation and the degree of differentiation. Conclusion there is a negative correlation between the differentiation of DCE-MRI and the degree of differentiation. Conclusion there is a negative correlation between the degree of differentiation and the degree of differentiation. Conclusion there is a negative correlation between DCE-MRI and the degree of differentiation. Conclusion there is a negative correlation between DCE-MRI and the degree of differentiation. Conclusion there is a negative correlation between the level of tumor differentiation and the degree of tumor differentiation. Conclusion the results show that there is a negative correlation between DCE-MRI and the degree of differentiation. Conclusion there is a negative correlation between the degree of differentiation and the degree of tumor differentiation. Conclusion there is a negative correlation between the degree of tumor differentiation and the level of tumor differentiation. Conclusion there is a negative correlation between DCE-MRI and the degree of differentiation of the tumor. Conclusion there is a negative correlation between the degree of differentiation and the degree of differentiation of the tumor. Conclusion the results show that there is a negative correlation between the degree of differentiation and the degree of differentiation. Quantitative parameters and T staging and lymph node metastasis of rectal cancer. There is a certain correlation between tumor differentiation degree and quantitative parameters can provide a certain reference value for the clinical prognosis of rectal cancer.
【作者单位】：甘肃省人民医院放射科;甘肃省人民医院肛肠科;
【基金】：甘肃省卫生行业科研计划基金资助项目(编号:GSWST2013-01)
【分类号】：R445.2;R735.37

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