Mohnarin脑脊液分离菌耐药性的动态分析

发布时间：2018-03-04 14:50

本文选题：全国细菌耐药性监测网脑脊液　切入点：微生物　出处：《中国药房》2016年02期 　论文类型：期刊论文

【摘要】：目的:为临床控制感染与经验治疗提供参考。方法:收集2006-2011年Mohnarin脑脊液分离菌报告文献资料,用SPSS.19.0软件进行统计。结果:我国2006-2011年临床脑脊液分离菌中革兰阳性(G~+)菌呈上升趋势,革兰阴性(G~-菌)呈下降趋势,且差异有统计学意义(χ~2=12.952,P=0.01)。葡萄球菌耐药率总体出现明显逐年下降的趋势,差异有统计学意义(P0.001),尤其是红霉素,对左氧氟沙星和环丙沙星的耐药率略有下降,但差异无统计学意义(P0.05);未发现金黄色葡萄球菌耐万古霉素、利奈唑胺菌株。肠球菌对万古霉素的耐药率明显上升,差异有统计学意义(P0.001),对左氧氟沙星耐药率差异无统计学意义(P0.05),未发现耐利奈唑胺菌株。G-菌对常用抗菌药物的耐药性均呈逐年上升趋势,以不动杆菌属多重耐药的情况较为严重,其对常用抗菌药物的耐药性明显逐年升高,差异有统计学意义(P0.001)。结论:我国脑脊液的临床分离菌中表皮葡萄球菌和不动杆菌属逐年增多,脑脊液的临床分离菌G~+菌耐药性大部分呈下降趋势,G~-菌均呈现明显增加趋势。
[Abstract]:Objective: to provide a reference for clinical control of infection and experience in treatment. Methods: collected the literature data of Mohnarin cerebrospinal fluid isolates from 2006 to 2011. Results: from 2006 to 2011, the clinical cerebrospinal fluid isolates of China showed an increasing trend of Gram-positive G ~ (~) and a decreasing trend of Gram-negative G ~ (-). And the difference was statistically significant (蠂 ~ (2 +) 12.952). The resistance rate of Staphylococcus to levofloxacin and ciprofloxacin decreased slightly. The resistance rate of staphylococcus to levofloxacin and ciprofloxacin decreased year by year, the difference was statistically significant (P 0.001), especially erythromycin, and the resistance rate to levofloxacin and ciprofloxacin decreased slightly. But the difference was not statistically significant (P 0.05). No vancomycin resistant strains of Staphylococcus aureus were found. The resistance rate of Enterococcus to vancomycin was significantly increased. The difference was statistically significant (P 0.001). There was no significant difference in the resistance rate of levofloxacin to levofloxacin (P 0.05). The drug resistance of alanzolamine resistant strain. G- was increased year by year, and the situation of Acinetobacter multidrug resistance was more serious than that of Acinetobacter multidrug resistance. The resistance to common antimicrobial agents increased year by year, and the difference was statistically significant (P 0.001). Conclusion: Staphylococcus epidermidis and Acinetobacter spp in clinical isolates of cerebrospinal fluid in China are increasing year by year. The drug resistance of the clinical isolates of cerebrospinal fluid (CSF) showed a decreasing trend.
【作者单位】：泉州医学高等专科学校基础医学部;福建医科大学附属泉州第一医院检验科;泉州医学高等专科学校护理系;福建医科大学附属第二医院神经外科;福建医科大学附属第二医院检验科;
【基金】：国家骨干院校建设重点资助项目(No.XJ1306;2014XJ1313) 2014年度泉州市社会发展领域科技计划项目(No.2014Z24) 2015年度泉州市社会发展领域科研与示范应用项目(No.2015Z93)
【分类号】：R446.5

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